RGD Reference Report - Absence of an interaction between the Rf-1 and Rf-5 QTLs influencing susceptibility to renal damage in rats. - Rat Genome Database

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Absence of an interaction between the Rf-1 and Rf-5 QTLs influencing susceptibility to renal damage in rats.

Authors: Van Dijk, SJ  Specht, PA  Lazar, J  Jacob, HJ  Provoost, AP 
Citation: van Dijk SJ, etal., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12.
RGD ID: 1582571
Pubmed: (View Article at PubMed) PMID:16837819
DOI: Full-text: DOI:10.1159/000094548

BACKGROUND: Previous studies showed that combining the Rf-1 and Rf-3 or Rf-4 QTLs of FHH induced synergistic interactions markedly enhancing renal susceptibility. The present study aimed to determine the presence of such interaction between the Rf-1 and Rf-5 QTLs. METHODS: Renal damage susceptibility was assessed in Rf-1B, Rf-1B+5, Rf-1B+4 congenics and ACI control rats in four situations: two-kidney control (2K), unilateral nephrectomy (UNX), L-NAME-induced hypertension (2K+L-NAME) and UNX+L-NAME. Albuminuria (UAV) and systolic blood pressure (SBP) were measured during 18 weeks of follow-up. In separate experiments, renal autoregulation was assessed in 2K rats. RESULTS: In all four situations, Rf-1B+4 rats developed more severe UAV than ACI, Rf-1B and Rf-1B+5. There were no significant differences in UAV between Rf-1B and Rf-1B+5 rats. In the 2K and UNX situation no differences in SBP were noted between all four strains. With 2K+L-NAME and UNX+L-NAME treatment, SBP in double congenics was higher than that of ACI and Rf-1B rats. Renal autoregulation was similarly impaired in all three congenic strains. CONCLUSION: We conclude that the Rf-5 region, alone or in the presence of Rf-1B, does not affect the development of renal damage. We cannot substantiate that the Rf-5 region contains genes influencing renal damage susceptibility.

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Objects referenced in this article
0 ACI/Eur August x Copenhagen Irish All species
0 FHH Fawn Hooded Hypertensive All species
0 Rf1 Renal disease susceptibility QTL 1 All species
0 Rf4 Renal disease susceptibility QTL 4 All species
0 Rf5 Renal disease susceptibility QTL 5 All species
0 SS/JrHsd Dahl Salt-Sensitive All species

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