RGD Reference Report - Delay fear conditioning modifies phospholipase C-beta 1a signaling in the hippocampus and frontal cortex. - Rat Genome Database

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Delay fear conditioning modifies phospholipase C-beta 1a signaling in the hippocampus and frontal cortex.

Authors: Weeber, EJ  Caldwell, KK 
Citation: Weeber EJ and Caldwell KK, Pharmacol Biochem Behav. 2004 May;78(1):155-64.
RGD ID: 1582559
Pubmed: PMID:15159145   (View Abstract at PubMed)
DOI: DOI:10.1016/j.pbb.2004.03.003   (Journal Full-text)

The use of the single-trial fear conditioning paradigm allows for control over the exact moment when an animal is exposed to a learning event, making it possible to study both the initial neurobiological changes that are associated with learning and changes that take place over long periods of time. In the present study, we performed detailed analyses of the alterations in phosphatidylinositol-specific phospholipase C-beta1a (PLC-beta1a) levels and enzyme activities in subcellular fractions prepared from the hippocampal formation (HPF) and medial frontal cortex (MFC) 1, 3, 5, 7, 24, and 72 h following single-trial fear conditioning. We observed tissue- and time-dependent changes in both PLC-beta1a enzyme activity and anti-PLC-beta1a immunoreactivity in each subcellular fraction. Based on these observations, we hypothesize that changes in PLC-beta1a catalytic activity and subcellular distribution play important roles in neuronal signaling processes that are required for fear-conditioned learning and memory.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
learning  IEP 1582559 RGD 
memory  IEP 1582559 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
phosphatidylinositol phospholipase C activity  IDA 1582559 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Plcb1  (phospholipase C beta 1)


Additional Information