RGD Reference Report - High expression of YB-1 gene in erythroid cells in patients with refractory anemia. - Rat Genome Database

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High expression of YB-1 gene in erythroid cells in patients with refractory anemia.

Authors: Yokoyama, H  Harigae, H  Takahashi, S  Kameoka, J  Miyamura, K  Ishizawa, K  Kaku, M  Sasaki, T 
Citation: Yokoyama H, etal., Int J Hematol. 2003 Oct;78(3):213-8.
RGD ID: 1580637
Pubmed: PMID:14604279   (View Abstract at PubMed)

It has been shown that aberrant expression of a transcription factor, GATA-1, leads to maturation arrest and transformation of erythroid cells. We previously reported that a multifunctional protein, YB-1, was expressed strongly in the spleen of a GATA-1 mutant mouse, which was filled with transformed erythroblasts. This finding suggested that YB-1 has roles in erythropoiesis. In this study, we examined in vivo expression of YB-1 messenger RNA (mRNA) in bone marrow erythroid cells and erythroid leukemic cell lines. During erythroid differentiation of erythroid leukemic cell lines, the expression level of YB-1 mRNA was highest at the early phase of differentiation and then decreased. In human bone marrow cells, the in vivo expression level of YB-1 mRNA was higher in glycophorin A-positive cells than in glycophorin A-negative cells. An interesting finding was that expression of YB-1 was higher in erythroblasts in myelodysplastic syndrome-refractory anemia (MDS-RA) than in normal cells. The findings suggested that YB-1 functions in the early stage of erythropoiesis and that aberrant expression of this protein may induce hematological diseases such as MDS.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Refractory Anemia  IEP 1580637 RGD 
Refractory Anemia  ISOYBX1 (Homo sapiens)1580637 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ybx1  (Y box binding protein 1)

Genes (Homo sapiens)
YBX1  (Y-box binding protein 1)


Additional Information