RGD Reference Report - Elevated growth-arrest-specific protein 6 plasma levels in patients with severe sepsis. - Rat Genome Database

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Elevated growth-arrest-specific protein 6 plasma levels in patients with severe sepsis.

Authors: Borgel, D  Clauser, S  Bornstain, C  Bieche, I  Bissery, A  Remones, V  Fagon, JY  Aiach, M  Diehl, JL 
Citation: Borgel D, etal., Crit Care Med. 2006 Jan;34(1):219-22.
RGD ID: 1579935
Pubmed: PMID:16374177   (View Abstract at PubMed)

OBJECTIVE: Growth-arrest-specific protein 6 (Gas6), an intracellular protein released by apoptotic cells, has been detected in normal plasma. As the Gas6 system has been implicated in mouse susceptibility to sepsis, and as leukocyte apoptosis is thought to play a major role in the physiopathology of human severe sepsis, we studied Gas6 plasma levels and possibly related variables in patients with severe sepsis. DESIGN: Matched case-control study. SETTING: Adult intensive care unit in a university hospital. PATIENTS: Thirty patients with severe sepsis, 30 patients with organ failure not related to infection, and 30 healthy subjects matched for age and gender. INTERVENTIONS: Blood draw. MEASUREMENTS AND MAIN RESULTS: Gas6 plasma levels were quantified using enzyme-linked immunosorbent assay. Whole-blood gas6 messenger RNA levels were measured by quantitative real-time polymerase chain reaction. Gas6 plasma levels were elevated (110 ng/mL [75, 139]; median values [interquartile range]) in severe sepsis patients compared with organ failure patients (85 ng/mL [56, 101]) and healthy subjects (54 ng/mL [49, 68]). In patients with severe sepsis, this increase correlated with the Acute Physiology and Chronic Health Evaluation II severity score, the organ failure Organ Dysfunction and Infection (ODIN) score, and the existence of a septic shock. Gas6 messenger RNA levels were increased in patients with severe sepsis and correlated specifically with the monocyte count. CONCLUSIONS: In severe sepsis, the recently described anti-apoptotic protein Gas6 was found at high levels in plasma and correlated well with the degree of organ dysfunction.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Sepsis  IDA 1579935 RGD 
Sepsis  ISOGAS6 (Homo sapiens)1579935; 1579935 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gas6  (growth arrest specific 6)

Genes (Mus musculus)
Gas6  (growth arrest specific 6)

Genes (Homo sapiens)
GAS6  (growth arrest specific 6)


Additional Information