RGD Reference Report - FLRT3 is expressed in sensory neurons after peripheral nerve injury and regulates neurite outgrowth. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

FLRT3 is expressed in sensory neurons after peripheral nerve injury and regulates neurite outgrowth.

Authors: Robinson, M  Parsons Perez, MC  Tebar, L  Palmer, J  Patel, A  Marks, D  Sheasby, A  De Felipe, C  Coffin, R  Livesey, FJ  Hunt, SP 
Citation: Robinson M, etal., Mol Cell Neurosci. 2004 Oct;27(2):202-14.
RGD ID: 1579783
Pubmed: PMID:15485775   (View Abstract at PubMed)
DOI: DOI:10.1016/j.mcn.2004.06.008   (Journal Full-text)

We used a molecular screen to identify genes upregulated in regenerating adult rat dorsal root ganglion cells. FLRT3 mRNA and protein characterized by a fibronectin type III domain and a leucine-rich repeat motif was upregulated in damaged sensory neurons. The protein was then transported into their peripheral and central processes where the FLRT3 protein was localized to presynaptic axon terminals. In vitro, the FLRT3 protein was expressed at the cell surface, regulated neurite outgrowth in sensory neurons, but did not exhibit homophilic binding. FLRT3 was widely expressed in the developing embryo, particularly in the central nervous system and somites. However, in the adult, we found no evidence for accumulation or reexpression of the FLRT3 protein in damaged axons of the central nervous system. We conclude that FLRT3 codes for a putative cell surface receptor implicated in both the development of the nervous system and in the regeneration of the peripheral nervous system (PNS).

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
neuron projection development involved_inIMP 1579783PMID:15485775UniProt 
neuron projection extension involved_inIMP 1579783PMID:15485775UniProt 
response to axon injury involved_inIMP 1579783PMID:15485775UniProt 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
axon terminus located_inIDA 1579783PMID:15485775UniProt 
plasma membrane located_inIDA 1579783PMID:15485775UniProt 
synaptic membrane located_inIDA 1579783PMID:15485775UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Flrt3  (fibronectin leucine rich transmembrane protein 3)


Additional Information