RGD Reference Report - Cytoskeleton-related trafficking of the EAAC1 glutamate transporter after activation of the G(q/11)-coupled neurotensin receptor NTS1. - Rat Genome Database

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Cytoskeleton-related trafficking of the EAAC1 glutamate transporter after activation of the G(q/11)-coupled neurotensin receptor NTS1.

Authors: Najimi, M  Maloteaux, JM  Hermans, E 
Citation: Najimi M, etal., FEBS Lett. 2002 Jul 17;523(1-3):224-8.
RGD ID: 1566569
Pubmed: PMID:12123836   (View Abstract at PubMed)

The possible modulation of the glutamate transporter EAAC1 by a class A G protein-coupled receptor was studied in transfected C6 glioma cells stably expressing the high-affinity neurotensin receptor NTS1. Brief exposure (5 min) to neurotensin increased Na(+)-dependent D-[(3)H]aspartate uptake by about 70%. The effect of neurotensin was found to result from an increase in cell surface expression of EAAC1 and accordingly, cytochalasin D and colchicine were shown to block the effect of neurotensin on aspartate uptake, suggesting that the cytoskeleton participates in this regulation. Neither protein kinase C nor phosphatidylinositol 3-kinase activities, two intracellular signaling pathways known to modulate EAAC1, was required for EAAC1-mediated aspartate transport regulation by neurotensin. Together, these results provide evidence for an acute regulation of EAAC1 trafficking after activation of a G protein-coupled receptor.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
D-aspartate import across plasma membrane  IDA 1566569 RGD 
L-glutamate import across plasma membrane  IDA 1566569 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ntsr1  (neurotensin receptor 1)


Additional Information