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Regulation of cullin-based ubiquitin ligases by the Nedd8/RUB ubiquitin-like proteins.

Authors: Parry, G  Estelle, M 
Citation: Parry G and Estelle M, Semin Cell Dev Biol. 2004 Apr;15(2):221-9.
Pubmed: (View Article at PubMed) PMID:15209382

The expression of the ubiquitin related protein Nedd8/RUB is essential for growth in most organisms. Nedd8/RUB has been shown to modify the cullin subunit of culling-based ubiquitin protein ligases (E3). Neddylation acts to regulate the function of these E3s and organisms with lesions in the neddylation process exhibit severe growth defects. In this review we describe the proteins that participate in neddylation and discuss a model for Nedd8/RUB regulation of ubiquitin ligase function.


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RGD Object Information
RGD ID: 1559298
Created: 2006-01-24
Species: All species
Last Modified: 2006-01-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.