RGD Reference Report - The MICAL proteins and rab1: a possible link to the cytoskeleton? - Rat Genome Database

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The MICAL proteins and rab1: a possible link to the cytoskeleton?

Authors: Fischer, J  Weide, T  Barnekow, A 
Citation: Fischer J, etal., Biochem Biophys Res Commun. 2005 Mar 11;328(2):415-23.
RGD ID: 1559290
Pubmed: PMID:15694364   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2004.12.182   (Journal Full-text)

The small GTPase rab1 plays a role in vesicle trafficking between ER and the Golgi complex. Recently, MICAL-1 was identified as new rab1 interacting protein. In this study, we show an interaction between two additional members of the MICAL family and rab1 in a yeast two-hybrid approach and GST pulldown experiments. We present data about the previously uncharacterized MICAL-3 concerning tissue distribution, size, and cellular localization. Furthermore, we investigated the connection between MICAL proteins and the cytoskeleton. Using the microtubule depolymerizing drug nocodazole we detected a link between MICAL-1 and -3, and the microtubule cytoskeleton.

Objects referenced in this article
Gene Mical1 microtubule associated monooxygenase, calponin and LIM domain containing 1 Rattus norvegicus
Gene Mical3 microtubule associated monooxygenase, calponin and LIM domain containing 3 Rattus norvegicus

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