RGD Reference Report - Acupuncture attenuates cognitive impairments in vascular dementia through inhibiting miR-143-3p. - Rat Genome Database

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Acupuncture attenuates cognitive impairments in vascular dementia through inhibiting miR-143-3p.

Authors: Yang, Runcheng  Yang, Jianhua  Huang, Lanfang 
Citation: Yang R, etal., Acta Biochim Pol. 2022 Dec 2;69(4):805-810. doi: 10.18388/abp.2020_6132.
RGD ID: 155882588
Pubmed: PMID:36459592   (View Abstract at PubMed)
DOI: DOI:10.18388/abp.2020_6132   (Journal Full-text)


BACKGROUND: Acupuncture can be used to treat vascular dementia (VD), but the underlying mechanism remains unclear. This study aimed to investigate the expression and clinical significance of microRNA-143-3p (miR-143-3p) in VD patients and explore whether acupuncture ameliorates VD by regulating miR-143-3p.
METHODS: Cognitive function and daily living ability in VD patients were assessed by mini-mental state examination, Hasegawa's dementia scale and activities of daily living scale, respectively. VD model of male Wistar rats was established using permanent bilateral common carotid artery occlusion. The expression level of miR-143-3p was measured by quantitative real-time PCR. Morris water maze test was used to assess the cognitive function of VD rat model. Receiver operating characteristic analysis was used to assess the diagnostic value of miR-143-3p in VD patients. Correlations between variables were analyzed by Pearson's correlation analysis.
RESULTS: Increased serum miR-143-3p expression in VD patients had a high diagnostic value to screen VD patients. Serum miR-143-3p level in VD patients after acupuncture treatment was decreased. After acupuncture treatment, serum miR-143-3p was negatively correlated with cognitive function and daily living ability in VD patients. miR-143-3p level was increased in VD rats, and the suppressive effects of acupuncture on miR-143-3p levels were relieved by miR-143-3p mimic. Overexpression of miR-143-3p reversed the ameliorative effect of acupuncture on cognitive functions of VD rats.
CONCLUSION: Serum miR-143-3p expression is upregulated in VD patients and downregulated in VD patients after acupuncture treatment. Additionally, acupuncture treatment may attenuate cognitive impairments in VD by suppressing miR-143-3p.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
vascular dementia exacerbatesISOMir143 (Rattus norvegicus)155882588; 155882588 RGD 
vascular dementia treatmentIEP 155882588 RGD 
vascular dementia treatmentISOMIR143 (Homo sapiens)155882588; 155882588 RGD 
vascular dementia exacerbatesIDA 155882588 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mir143  (microRNA 143)

Genes (Mus musculus)
Mir143  (microRNA 143)

Genes (Homo sapiens)
MIR143  (microRNA 143)


Additional Information