RGD Reference Report - Association of Elongation Factor Tu GTP-binding Domain-containing 2 Gene (EFTUD2) Polymorphism with the Risk of Hepatitis B Virus Infection. - Rat Genome Database

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Association of Elongation Factor Tu GTP-binding Domain-containing 2 Gene (EFTUD2) Polymorphism with the Risk of Hepatitis B Virus Infection.

Authors: Tian, Anran  Li, Yuwen  Fan, Haozhi  Hu, Pingping  Xu, Ruirui  Yuan, Hui  Cai, Jinyuan  Zhang, Wen  Yue, Ming  Li, Jun  Dong, Chen  Zhu, Chuanlong 
Citation: Tian A, etal., Immunol Invest. 2022 Jul;51(5):1485-1497. doi: 10.1080/08820139.2021.1970763. Epub 2021 Aug 26.
RGD ID: 155791665
Pubmed: PMID:34436958   (View Abstract at PubMed)
DOI: DOI:10.1080/08820139.2021.1970763   (Journal Full-text)


BACKGROUND: The elongation factor Tu GTP-binding domain-containing 2 gene (EFTUD2) participates in antiviral immune responses. However, the association between genetic polymorphisms of EFTUD2 and hepatitis B virus (HBV) infection susceptibility has not been well-studied. We analyzed the relationship between single nucleotide polymorphisms (SNPs) of EFTUD2 and HBV infection susceptibility and clarified the potential function.
METHODS: In total, 448 control subjects and 379 patients with chronic HBV infection from Zhangjiagang First People's Hospital (Jiangsu, China) were enrolled. Sequenom iPLEX assay was used to detect genotypes of four SNPs (rs1071682, rs2277617, rs2289674, and rs3809756). Dual-luciferase reporter vectors with wild-type A and mutant-type C alleles of EFTUD2 rs3809756 were transfected into HepG2 cells to explore effects on transcription activity.
RESULTS: Only rs3809756 was significantly associated with HBV infection susceptibility (P < .05). The risk of HBV infection was higher in individuals carrying the rs3809756-CC genotype than in those carrying the rs3809756-AA genotype (odds ratio [OR] = 1.945, 95% confidence interval [CI] = 1.129-3.351, P = .017). Subgroup analysis based on the dominant model revealed that rs3809756-AC and rs3809756-CC carriers had a significantly higher risk of HBV infection than rs3809756-AA carriers among patients who were male (OR = 1.732, 95% CI = 1.218-2.464, P = .002), were aged >=47 years (OR = 1.502, 95% CI = 1.050-2.148, P = .026), or without liver cirrhosis (OR = 1.407, 95% CI = 1.077-1.838, P = .012). In the dual-luciferase reporter assay, the relative luciferase activity of rs3809756-C was significantly lower than that of rs3809756-A (P < .05).
CONCLUSION: EFTUD2 rs3809756A>C was associated with HBV infection susceptibility and might be involved in the downregulation of promoter activity.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
EFTUD2Humanhepatitis B susceptibilityIAGP  RGD 
Eftud2Mousehepatitis B susceptibilityISOEFTUD2 (Homo sapiens) RGD 
Eftud2Rathepatitis B susceptibilityISOEFTUD2 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Eftud2  (elongation factor Tu GTP binding domain containing 2)

Genes (Mus musculus)
Eftud2  (elongation factor Tu GTP binding domain containing 2)

Genes (Homo sapiens)
EFTUD2  (elongation factor Tu GTP binding domain containing 2)


Additional Information