RGD Reference Report - A novel member of the testis specific serine kinase family, tssk-3, expressed in the Leydig cells of sexually mature mice. - Rat Genome Database

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A novel member of the testis specific serine kinase family, tssk-3, expressed in the Leydig cells of sexually mature mice.

Authors: Zuercher, G  Rohrbach, V  Andres, AC  Ziemiecki, A 
Citation: Zuercher G, etal., Mech Dev 2000 May;93(1-2):175-7.
RGD ID: 1556651
Pubmed: PMID:10781952   (View Abstract at PubMed)

We have recently characterized two members of a novel family of murine testis specific serine kinases, tssk-1 and tssk-2, expressed exclusively in spermatids undergoing spermiogenesis. Using a differential screening approach we have isolated a third family member, tssk-3. The open reading frame of tssk-3 encodes a protein of 275 amino acids, consisting essentially of a serine/threonine protein kinase domain only. In contrast, tssk-1 and -2 have distinct, approximately 100 amino acid domains located C-terminally to the kinase domain. Immunoprecipitation experiments revealed that while tssk-1 and tssk-2 form detergent resistant complexes, tssk-3 is not associated with either protein. Expression of tssk-3 was induced at puberty, persisted during adulthood and was restricted to the interstitial Leydig cells of post-pubertal males.

Objects referenced in this article
Gene Tssk3 testis-specific serine kinase 3 Mus musculus
Gene Tssk3 testis-specific serine kinase 3 Rattus norvegicus

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