RGD Reference Report - Sorting of vesicular monoamine transporter 2 to the regulated secretory pathway confers the somatodendritic exocytosis of monoamines. - Rat Genome Database

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Sorting of vesicular monoamine transporter 2 to the regulated secretory pathway confers the somatodendritic exocytosis of monoamines.

Authors: Li, Haiyan  Waites, Clarissa L  Staal, Roland G  Dobryy, Yuriy  Park, Jeanna  Sulzer, David L  Edwards, Robert H 
Citation: Li H, etal.
RGD ID: 155663549
Pubmed: PMID:16301178   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neuron.2005.09.033   (Journal Full-text)

The release of monoamine neurotransmitters from cell bodies and dendrites has an important role in behavior, but the mechanism (vesicular or non vesicular) has remained unclear. Because the location of vesicular monoamine transporter 2 (VMAT2) defines the secretory vesicles capable of monoamine release, we have studied its trafficking to assess the potential for monoamine release by exocytosis. In neuroendocrine PC12 cells, VMAT2 localizes exclusively to large dense-core vesicles (LDCVs), and we now show that cytoplasmic signals target VMAT2 directly to LDCVs within the biosynthetic pathway. In neurons, VMAT2 localizes to a population of vesicles that we now find undergo regulated exocytosis in dendrites. Although hippocampal neurons do not express typical LDCV proteins, transfected chromogranins A, B, and brain-derived neurotrophic factor (BDNF) colocalize with VMAT2. VMAT2 thus defines a population of secretory vesicles that mediate the activity-dependent somatodendritic release of multiple retrograde signals involved in synaptic function, growth, and plasticity.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Slc18a2Ratsomato-dendritic dopamine secretion involved_inIDA PMID:16301178UniProt 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Slc18a2Rataxon located_inIDA PMID:16301178UniProt 
Slc18a2Ratdendrite located_inIDA PMID:16301178UniProt 
Slc18a2Ratsecretory granule membrane located_inIDA PMID:16301178UniProt 
Slc18a2Ratsynaptic vesicle membrane located_inIDA PMID:16301178UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Slc18a2  (solute carrier family 18 member A2)


Additional Information