RGD Reference Report - Identification of a family of human F-box proteins. - Rat Genome Database

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Identification of a family of human F-box proteins.

Authors: Cenciarelli, C  Chiaur, DS  Guardavaccaro, D  Parks, W  Vidal, M  Pagano, M 
Citation: Cenciarelli C, etal., Curr Biol 1999 Oct 21;9(20):1177-9.
RGD ID: 1556499
Pubmed: PMID:10531035   (View Abstract at PubMed)
DOI: DOI:10.1016/S0960-9822(00)80020-2   (Journal Full-text)

F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 aminoacid motif, the F box (so named because cyclin F was one of the first proteins in which this motif was identified) [1]. Some F-box proteins have been shown to be critical for the controlled degradation of cellular regulatory proteins [2] [3]. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases called SCFs. The other three subunits are the Skp1 protein; one of the cullin proteins (Cul1 in metazoans and Cdc53 or Cul A in the yeast Saccharomyces cerevisiae); and the recently identified Roc1 protein (also called Rbx1 or Hrt1). SCF ligases bring ubiquitin conjugating enzymes (either Ubc3 or Ubc4) to substrates that are specifically recruited by the different F-box proteins. The need for high substrate specificity and the large number of known F-box proteins in yeast and worms [2] [4] suggest the existence of a large family of mammalian F-box proteins. Using Skp1 as a bait in a yeast two-hybrid screen and by searching DNA databases, we identified a family of 26 human F-box proteins, 25 of which were novel. Some of these proteins contained WD-40 domains or leucine-rich repeats; others contained either different protein-protein interaction modules or no recognizable motifs. We have named the F-box proteins that contain WD-40 domains Fbws, those containing leucine-rich repeats, Fbls, and the remaining ones Fbxs. We have further characterized representative members of these three classes of F-box proteins.

Objects referenced in this article
Gene Fbxl6 F-box and leucine-rich repeat protein 6 Rattus norvegicus

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