RGD Reference Report - Hereditary cerebellar vermis defect in the Lewis rat. - Rat Genome Database

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Hereditary cerebellar vermis defect in the Lewis rat.

Authors: Kuwamura, M  Yoshida, T  Yamate, J  Kotani, T  Sakuma, S 
Citation: Kuwamura M, etal., Brain Res Dev Brain Res 1994 Dec 16;83(2):294-8.
RGD ID: 1553899
Pubmed: (View Article at PubMed) PMID:7697886

We report a new rat model of hereditary cerebellar vermis defect. Mutant rats exhibited hind-leg paralysis from about 14 days old. Gross pathology showed the cerebellar vermis defect, fused cerebellar hemispheres and cyst formation. Ectopic dysplastic cerebellar tissues existed in the cerebello-pontine junctional zones. Mild disarrangement of lamination was also observed in the fused cerebellar hemispheres. The present mutant may serve as a valid model for studying the cerebellar vermis defect under the genetic control.

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Objects referenced in this article
Strain CVD/Opu Cerebellar vermis defect rat Rattus norvegicus
Strain F344.CVD-Unc5ccvd/Kyo null Rattus norvegicus

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