RGD Reference Report - Genome screen for bone mineral density phenotypes in Fisher 344 and Lewis rat strains. - Rat Genome Database

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Genome screen for bone mineral density phenotypes in Fisher 344 and Lewis rat strains.

Authors: Koller, DL  Alam, I  Sun, Q  Liu, L  Fishburn, T  Carr, LG  Econs, MJ  Foroud, T  Turner, CH 
Citation: Koller DL, etal., Mamm Genome 2005 Aug;16(8):578-86. Epub 2005 Sep 14.
RGD ID: 1553896
Pubmed: PMID:16180139   (View Abstract at PubMed)
DOI: DOI:10.1007/s00335-004-2459-0   (Journal Full-text)

In humans, peak bone mineral density (BMD) is the primary determinant of osteoporotic fracture risk among older individuals, with high peak BMD levels providing protection against osteoporosis in the almost certain event of bone loss later in life. A genome screen to identify quantitative trait loci (QTLs) contributing to areal BMD (aBMD) and volumetric BMD (vBMD) measurements at the lumbar spine and femoral neck was completed in 595 female F2 rats produced from reciprocal crosses of inbred Fischer 344 and Lewis rats. Significant evidence of linkage was detected to rat Chromosomes 1, 2, 8, and 10, with LOD scores above 8.0. The region on rat Chromosome 8 is syntenic to human Chromosome 15, where linkage to spine and femur BMD has been previously reported and confirmed in a sample of premenopausal women.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bmd1Ratosteoporosis  IAGP  RGD 
Bmd2Ratosteoporosis  IAGP  RGD 
Bmd3Ratosteoporosis  IAGP  RGD 
Bmd4Ratosteoporosis  IAGP  RGD 
Bmd5Ratosteoporosis  IAGP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bmd1Ratincreased bone mineral density  IAGP  RGD 
Bmd2Ratincreased bone mineral density  IAGP  RGD 
Bmd3Ratincreased bone mineral density  IAGP  RGD 
Bmd4Ratincreased bone mineral density  IAGP  RGD 
Bmd5Ratincreased bone mineral density  IAGP  RGD 

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Objects Annotated

QTLs
Bmd1  (Bone mineral density QTL 1)
Bmd2  (Bone mineral density QTL 2)
Bmd3  (Bone mineral density QTL 3)
Bmd4  (Bone mineral density QTL 4)
Bmd5  (Bone mineral density QTL 5)

Strains
F344  (Fischer)
LEW  (Lewis)


Additional Information