RGD Reference Report - A crosstalk between β1 and β3 integrins controls glycine receptor and gephyrin trafficking at synapses. - Rat Genome Database

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A crosstalk between β1 and β3 integrins controls glycine receptor and gephyrin trafficking at synapses.

Authors: Charrier, Cécile  Machado, Patricia  Tweedie-Cullen, Ry Y  Rutishauser, Dorothea  Mansuy, Isabelle M  Triller, Antoine 
Citation: Charrier C, etal., Nat Neurosci. 2010 Nov;13(11):1388-95. doi: 10.1038/nn.2645. Epub 2010 Oct 10.
RGD ID: 155230798
Pubmed: PMID:20935643   (View Abstract at PubMed)
DOI: DOI:10.1038/nn.2645   (Journal Full-text)

The regulation of glycine receptor (GlyR) number at synapses is necessary for the efficacy of inhibition and the control of neuronal excitability in the spinal cord. GlyR accumulation at synapses depends on the scaffolding molecule gephyrin and is linked to GlyR synaptic dwell time. However, the mechanisms that tune GlyR synaptic exchanges in response to different neuronal environments are unknown. Integrins are cell adhesion molecules and signaling receptors. Using single quantum dot imaging and fluorescence recovery after photobleaching, we found in rats that β1 and β3 integrins adjust synaptic strength by regulating the synaptic dwell time of both GlyRs and gephyrin. β1 and β3 integrins crosstalked via calcium/calmodulin-dependent protein kinase II and adapted GlyR lateral diffusion and gephyrin-dependent trapping at synapses. This provides a mechanism for maintaining or adjusting the steady state of postsynaptic molecule exchanges and the level of glycinergic inhibition in response to neuron- and glia-derived signals or extracellular matrix remodeling.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Itgb1Ratglycinergic synapse is_active_inEXP PMID:20935643SynGO 
Itgb1Ratglycinergic synapse is_active_inIDA PMID:20935643SynGO 
Itgb3Ratglycinergic synapse is_active_inEXP PMID:20935643SynGO 
Itgb3Ratglycinergic synapse is_active_inIDA PMID:20935643SynGO 

Objects Annotated

Genes (Rattus norvegicus)
Itgb1  (integrin subunit beta 1)
Itgb3  (integrin subunit beta 3)


Additional Information