RGD Reference Report - BDNF-mediated neurotransmission relies upon a myosin VI motor complex. - Rat Genome Database

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BDNF-mediated neurotransmission relies upon a myosin VI motor complex.

Authors: Yano, Hiroko  Ninan, Ipe  Zhang, Hong  Milner, Teresa A  Arancio, Ottavio  Chao, Moses V 
Citation: Yano H, etal., Nat Neurosci. 2006 Aug;9(8):1009-18. doi: 10.1038/nn1730. Epub 2006 Jul 2.
RGD ID: 155230717
Pubmed: PMID:16819522   (View Abstract at PubMed)
DOI: DOI:10.1038/nn1730   (Journal Full-text)

Brain-derived neurotrophic factor (BDNF) has been implicated in higher-order cognitive functions and in psychiatric disorders such as depression and schizophrenia. BDNF modulates synaptic transmission and plasticity primarily through the TrkB receptor, but the molecules involved in BDNF-mediated synaptic modulation are largely unknown. Myosin VI (Myo6) is a minus end-directed actin-based motor found in neurons that express Trk receptors. Here we report that Myo6 and a Myo6-binding protein, GIPC1, form a complex that can engage TrkB. Myo6 and GIPC1 were necessary for BDNF-TrkB-mediated facilitation of long-term potentiation in postnatal day 12-13 (P12-13) hippocampus. Moreover, BDNF-mediated enhancement of glutamate release from presynaptic terminals depended not only upon TrkB but also upon Myo6 and GIPC1. Similar defects in basal synaptic transmission as well as presynaptic properties were observed in Myo6 and GIPC1 mutant mice. Together, these results define an important role for the Myo6-GIPC1 motor complex in presynaptic function and in BDNF-TrkB-mediated synaptic plasticity.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Gipc1Ratpostsynapse is_active_inIDA PMID:16819522SynGO 
Gipc1Ratpresynapse is_active_inIDA PMID:16819522SynGO 
Gipc1RatSchaffer collateral - CA1 synapse is_active_inIDA PMID:16819522SynGO 

Objects Annotated

Genes (Rattus norvegicus)
Gipc1  (GIPC PDZ domain containing family, member 1)


Additional Information