RGD Reference Report - Hague (Hag). A new mouse hair mutation with an unstable semidominant allele. - Rat Genome Database

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Hague (Hag). A new mouse hair mutation with an unstable semidominant allele.

Authors: Poirier, C  Yoshiki, A  Fujiwara, K  Guenet, JL  Kusakabe, M 
Citation: Poirier C, etal., Genetics 2002 Oct;162(2):831-40.
RGD ID: 1549612
Pubmed: PMID:12399393   (View Abstract at PubMed)
PMCID: PMC1462301   (View Article at PubMed Central)

A spontaneous mouse hair mutation was identified in a C3H/HeN colony. The mode of inheritance of the mutation was semidominant, with incomplete penetrance when heterozygous. The trait is controlled by a single locus hague (Hag), which was mapped to the telomeric region of chromosome 15. This mutation was shown to be unstable, since its transmission could be switched from semidominant to recessive. To identify the causative gene and the nature of the mutation, hague was introduced into a high-resolution and high-density molecular genetic map. Over 2000 meioses were analyzed and the mutation was mapped to the keratin 2 complex genes. A YAC and BAC physical map of the critical region was then constructed and the gene involved was located in a 600- to 800-kb-long segment. Fourteen genes were mapped to this region; of these, 11 were expressed in the skin (5 epidermic cytokeratin and 6 hard keratin genes), but none were mutated in hague mice.

Objects referenced in this article
Gene Krt1 keratin 1 Mus musculus
Gene Krt18 keratin 18 Mus musculus
Gene Krt2 keratin 2 Mus musculus
Gene Krt4 keratin 4 Mus musculus
Gene Krt5 keratin 5 Mus musculus
Gene Krt7 keratin 7 Mus musculus
Gene Krt75 keratin 75 Mus musculus
Gene Krt8 keratin 8 Mus musculus
Gene Krt81 keratin 81 Mus musculus
Gene Krt82 keratin 82 Mus musculus
Gene Krt84 keratin 84 Mus musculus
Gene Krt85 keratin 85 Mus musculus
Gene Krt86 keratin 86 Mus musculus

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