RGD Reference Report - Neuropilin-2 regulates the development of selective cranial and sensory nerves and hippocampal mossy fiber projections. - Rat Genome Database

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Neuropilin-2 regulates the development of selective cranial and sensory nerves and hippocampal mossy fiber projections.

Authors: Chen, H  Bagri, A  Zupicich, JA  Zou, Y  Stoeckli, E  Pleasure, SJ  Lowenstein, DH  Skarnes, WC  Chedotal, A  Tessier-Lavigne, M 
Citation: Chen H, etal., Neuron 2000 Jan;25(1):43-56.
RGD ID: 1549593
Pubmed: PMID:10707971   (View Abstract at PubMed)

Neuropilin-1 and neuropilin-2 bind differentially to different class 3 semaphorins and are thought to provide the ligand-binding moieties in receptor complexes mediating repulsive responses to these semaphorins. Here, we have studied the function of neuropilin-2 through analysis of a neuropilin-2 mutant mouse, which is viable and fertile. Repulsive responses of sympathetic and hippocampal neurons to Sema3F but not to Sema3A are abolished in the mutant. Marked defects are observed in the development of several cranial nerves, in the initial central projections of spinal sensory axons, and in the anterior commissure, habenulo-interpeduncular tract, and the projections of hippocampal mossyfiber axons in the infrapyramidal bundle. Our results show that neuropilin-2 is an essential component of the Sema3F receptor and identify key roles for neuropilin-2 in axon guidance in the PNS and CNS.

Objects referenced in this article
Gene Calb2 calbindin 2 Mus musculus
Gene Cntn2 contactin 2 Mus musculus
Gene Lef1 lymphoid enhancer binding factor 1 Mus musculus
Gene Neurod6 neurogenic differentiation 6 Mus musculus
Gene Nrp2 neuropilin 2 Mus musculus
Gene Prox1 prospero homeobox 1 Mus musculus
Gene Slc30a3 solute carrier family 30 (zinc transporter), member 3 Mus musculus

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