RGD Reference Report - EMX2 is epigenetically silenced and suppresses epithelial‑mesenchymal transition in human esophageal adenocarcinoma. - Rat Genome Database

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EMX2 is epigenetically silenced and suppresses epithelial‑mesenchymal transition in human esophageal adenocarcinoma.

Authors: Wang, Lei  Jin, Joy  Zhou, Yong  Tian, Ziqiang  He, Biao  Huang, Yueyan  Ding, Feng 
Citation: Wang L, etal., Oncol Rep. 2019 Nov;42(5):2169-2178. doi: 10.3892/or.2019.7284. Epub 2019 Aug 20.
RGD ID: 153323302
Pubmed: PMID:31432154   (View Abstract at PubMed)
DOI: DOI:10.3892/or.2019.7284   (Journal Full-text)

Esophageal adenocarcinoma (EAC) is an aggressive and challenging disease to treat, with an overall five‑year survival rate of <20%. Early malignant cell dissemination contributes to this poor prognosis. Epithelial‑mesenchymal transition (EMT) induces the invasion and metastasis of carcinoma cells. Empty spiracles homeobox 2 (EMX2) is a homeodomain‑containing transcription factor, which is associated with numerous cancer types, and has been demonstrated to regulate EMT. In the present study, 48 pairs of EAC and adjacent normal tissues were analyzed. The results revealed that EMX2 was downregulated in EAC tissues, and its expression was negatively correlated with the DNA hypermethylation of its promoter. Additionally, the OE19 and OE33 EAC cell lines were treated with the DNA methyltransferase inhibitor 5‑aza‑2'‑deoxycytidine, and the results indicated that EMX2 expression was increased. Overexpressing EMX2 in EAC cell lines enhanced the expression of apoptotic markers, inhibited cell migration and invasion, led to the upregulation of E‑cadherin and the downregulation of mesenchymal markers, and suppressed AKT, mTOR and S6K phosphorylation. Furthermore, EMX2 overexpression sensitized EAC cells to cisplatin. These results demonstrated that EMX2 inhibited the AKT/mTOR/S6K signaling pathway and decreased EMT. However, the downregulation of EMX2 was revealed to be associated with EMT in EAC, indicating that EMX2 may be a potential target for the management of EAC.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
esophagus adenocarcinoma  IEP 153323302protein:decreased expression:esophagus (human)RGD 
esophagus adenocarcinoma  ISOEMX2 (Homo sapiens)153323302; 153323302protein:decreased expression:esophagus (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Emx2  (empty spiracles homeobox 2)

Genes (Mus musculus)
Emx2  (empty spiracles homeobox 2)

Genes (Homo sapiens)
EMX2  (empty spiracles homeobox 2)


Additional Information