RGD Reference Report - Prognostic role of BAP-1 and PBRM-1 expression in intrahepatic cholangiocarcinoma. - Rat Genome Database

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Prognostic role of BAP-1 and PBRM-1 expression in intrahepatic cholangiocarcinoma.

Authors: Sarcognato, Samantha  Gringeri, Enrico  Fassan, Matteo  Di Giunta, Michela  Maffeis, Valeria  Guzzardo, Vincenza  Cillo, Umberto  Guido, Maria 
Citation: Sarcognato S, etal., Virchows Arch. 2019 Jan;474(1):29-37. doi: 10.1007/s00428-018-2478-y. Epub 2018 Oct 30.
RGD ID: 152998946
Pubmed: PMID:30377796   (View Abstract at PubMed)
DOI: DOI:10.1007/s00428-018-2478-y   (Journal Full-text)

Intrahepatic cholangiocarcinoma (ICC) has universally poor outcome, mainly due to its late clinical presentation. Identification of specific biomarkers and development of effective treatment are still urgently required. Mutations in PBRM-1 and BAP-1 genes, and the expression of S100P have been related to survival in ICC. miR-31 seems also to play important regulatory functions in ICC and it directly regulates BAP-1 expression in lung cancer. In this study, tissue expression of BAP-1, PBRM-1, S100P, and miR-31 was investigated in ICC and correlated with clinical-pathological features. Sixty-one consecutive patients who underwent curative hepatic resection for ICC were enrolled. None received any therapy prior to surgery. Immunostaining for BAP-1, PBRM-1, and S100P, and in situ hybridization for miR-31 were performed, using tissue microarray slides. A strong retained expression of BAP-1 and PBRM-1 was associated with a reduced overall (p = 0.04 and p = 0.002, respectively) and disease-free survival (p = 0.05 and p = 0.02, respectively). An overexpression of S100P was related to a reduced overall survival (p = 0.005). The multivariate analyses identified the presence of perineural invasion and the retained PBRM-1 expression as independent predictors of worse overall [p = 0.02, hazard ratio (HR) = 2.25 (1.16-4.39) and p = 0.001, HR = 3.13 (1.56-6.28), respectively] and disease-free survivals [p = 0.03, HR = 2.43 (1.09-5.4) and p = 0.03, HR = 2.51 (1.11-5.67), respectively]. An overexpression of S100P was predictive of a worse overall survival [p = 0.02, HR = 1.66 (1.08-2.55)]. High levels of miR-31 were significantly associated to a low expression of BAP-1 protein (p = 0.03). In ICC, a retained expression of BAP-1 and PBRM-1, and an overexpression of S100P are related to a poor prognosis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
intrahepatic cholangiocarcinoma disease_progressionHEP 152998946; 152998946; 152998946protein:increased expression:intrahepatic bile duct (human)RGD 

Objects Annotated

Genes (Homo sapiens)
MAGI1  (membrane associated guanylate kinase, WW and PDZ domain containing 1)
PBRM1  (polybromo 1)
S100B  (S100 calcium binding protein B)


Additional Information