RGD Reference Report - [Expression of Rictor and mTOR in colorectal cancer and their clinical significance]. - Rat Genome Database

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[Expression of Rictor and mTOR in colorectal cancer and their clinical significance].

Authors: Wang, Li-Feng  Chen, Hai-Jin  Yu, Jin-Long  Qi, Jia  Lin, Xiao-Hua  Zou, Zhao-Wei 
Citation: Wang LF, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2016 Mar;36(3):396-400.
RGD ID: 152995519
Pubmed: PMID:27063170   (View Abstract at PubMed)


OBJECTIVE: To explore the expression of Rictor and mTOR in the colorectal cancer and their clinical significance.
METHODS: The expression levels of Rictor and mTOR in HCT116, SW480, LoVo and HCoEpiC cells were detected by indirect immunofluorescence and Western blotting. Sixty-two paraffin-embedded surgical specimens of colorectal cancer tissue and adjacent tissues were examined for Rictor expression using immunohistochemistry. The association of the expression levels of Rictor protein with the clinicopathologic features and the overall survival of the patients was analyzed.
RESULTS: The expression level of Rictor was significantly higher in colorectal cancer tissues than in the adjacent tissues (P<0.05). The expression levels of Rictor and mTOR in the colon cancer cell lines were higher than those in human normal colon epithelial cell line HCoEpiC. The expression of Rictor was correlated with Dukes stage and lymphatic metastasis of the tumors but not with other clinicopathological parameter (P>0.05). Patients with Rictor expression had a lower overall survival rate than those without Rictor expression.
CONCLUSION: Rictor overexpression is associated with the carcinogenesis and progression of colorectal cancer and can be an independent indicator for evaluating the prognosis of colorectal cancer patients.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
colorectal cancer disease_progressionIEP 152995519associated with Lymphatic Metastasis and protein:increased expression:colon (human)RGD 
colorectal cancer disease_progressionISORICTOR (Homo sapiens)152995519; 152995519associated with Lymphatic Metastasis and protein:increased expression:colon (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Rictor  (RPTOR independent companion of MTOR, complex 2)

Genes (Mus musculus)
Rictor  (RPTOR independent companion of MTOR, complex 2)

Genes (Homo sapiens)
RICTOR  (RPTOR independent companion of MTOR complex 2)


Additional Information