RGD Reference Report - Expression of Fas system-related genes in the testis during development and after toxicant exposure. - Rat Genome Database

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Expression of Fas system-related genes in the testis during development and after toxicant exposure.

Authors: Boekelheide, K  Lee, J  Shipp, E B  Richburg, J H  Li, G 
Citation: Boekelheide K, etal., Toxicol Lett. 1998 Dec 28;102-103:503-8. doi: 10.1016/s0378-4274(98)00242-2.
RGD ID: 152975630
Pubmed: PMID:10022303   (View Abstract at PubMed)
DOI: DOI:10.1016/s0378-4274(98)00242-2   (Journal Full-text)

The Fas system has been identified as a key regulator of testicular germ cell apoptosis. The goal of these experiments was to explore the expression of Fas system-related genes in the testis during development and after toxicant exposure. Both Fas ligand (FasL) and Fas receptor (Fas) were expressed postnatally in rat testis with peak expression associated with the high levels of germ cell apoptosis found during the first wave of spermatogenesis. The testicular expression of RIP and FAP-1, components of the Fas activating complex, increased after exposure to mono-(2-ethylhexyl)phthalate (MEHP), a Sertoli cell toxicant which induces massive germ cell death. Finally, the expression of additional apoptosis-inducing genes, including tumor necrosis factor receptor (TNFR), FADD, TRAIL, and DR5, was detected in mammalian testis. These results provide additional support for the following concepts: (1) Sertoli-germ cell interactions are important in the control of germ cell apoptosis; and (2) the Fas system and similar paracrine systems are important modulators of testicular homeostasis.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cellular response to toxic substance  IEP 152975630 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ptpn13  (protein tyrosine phosphatase, non-receptor type 13)


Additional Information