RGD Reference Report - The existence of a second vesicular glutamate transporter specifies subpopulations of glutamatergic neurons. - Rat Genome Database

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The existence of a second vesicular glutamate transporter specifies subpopulations of glutamatergic neurons.

Authors: Herzog, E  Bellenchi, G C  Gras, C  Bernard, V  Ravassard, P  Bedet, C  Gasnier, B  Giros, B  El Mestikawy, S 
Citation: Herzog E, etal., J Neurosci. 2001 Nov 15;21(22):RC181.
RGD ID: 151665720
Pubmed: PMID:11698619   (View Abstract at PubMed)
PMCID: PMC6762292   (View Article at PubMed Central)

Before their exocytotic release during stimulation of nerve terminals, nonpeptide neurotransmitters are loaded into synaptic vesicles by specific transporters. Recently, a protein initially identified as brain-specific Na(+)-dependent inorganic phosphate transporter I (BNPI) has been shown to represent a vesicular glutamate transporter (VGLUT1). In this study, we investigated whether a highly homologous "differentiation-associated Na(+)-dependent inorganic phosphate transporter" (DNPI) is involved in glutamatergic transmission. Vesicles isolated from BON cells expressing recombinant DNPI accumulated l-glutamate with bioenergetical and pharmacological characteristics identical to those displayed by VGLUT1 and by brain synaptic vesicles. Moreover, DNPI localized to synaptic vesicles, at synapses exhibiting classical excitatory features. DNPI thus represents a novel vesicular glutamate transporter (VGLUT2). The distributions of each VGLUT transcript in brain were highly complementary, with only a partial regional and cellular overlap. At the protein level, we could only detect either VGLUT1- or VGLUT2-expressing presynaptic boutons. The existence of two VGLUTs thus defines distinct subsets of glutamatergic neurons.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Slc17a6RatL-glutamate transmembrane transport involved_inIDA PMID:11698619UniProt 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Slc17a6Ratneuron projection located_inIDA PMID:11698619UniProt 
Slc17a6Ratsynaptic vesicle located_inIDA PMID:11698619UniProt 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Slc17a6RatL-glutamate uniporter activity enablesIDA PMID:11698619UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Slc17a6  (solute carrier family 17 member 6)


Additional Information