RGD Reference Report - ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins. - Rat Genome Database

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ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins.

Authors: Knoblach, Barbara  Keller, Bernd O  Groenendyk, Jody  Aldred, Sandi  Zheng, Jing  Lemire, Bernard D  Li, Liang  Michalak, Marek 
Citation: Knoblach B, etal., Mol Cell Proteomics. 2003 Oct;2(10):1104-19. doi: 10.1074/mcp.M300053-MCP200. Epub 2003 Aug 19.
RGD ID: 151356646
Pubmed: PMID:12930873   (View Abstract at PubMed)
DOI: DOI:10.1074/mcp.M300053-MCP200   (Journal Full-text)

Using a proteomic analysis of the luminal environment of the endoplasmic reticulum (ER), we have identified 141 proteins, of which 6 were previously unknown. Two newly discovered ER luminal proteins, designated ERp19 and ERp46, are related to protein disulphide isomerase. Western and Northern blot analyses revealed that both ERp19 and ERp46 and their respective mRNAs are highly expressed in the liver as compared with other tissues. Both proteins were enriched in purified liver ER vesicles and were localized specifically to the ER in McA-RH7777 hepatocytes. Functional analysis with yeast complementation studies showed that ERp46 but not ERp19 can substitute for protein disulphide isomerase function in vivo.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
endoplasmic reticulum lumen part_ofIDA 151356646PMID:12930873UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Txndc12  (thioredoxin domain containing 12)


Additional Information