RGD Reference Report - Ubiquitin ligase A20 regulates p53 protein in human colon epithelial cells. - Rat Genome Database

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Ubiquitin ligase A20 regulates p53 protein in human colon epithelial cells.

Authors: Liu, Jing  Yang, Shaobo  Wang, Zhiqiang  Chen, Xiao  Zhang, Ziqi 
Citation: Liu J, etal., J Biomed Sci. 2013 Oct 7;20:74. doi: 10.1186/1423-0127-20-74.
RGD ID: 151347624
Pubmed: PMID:24099634   (View Abstract at PubMed)
PMCID: PMC4021182   (View Article at PubMed Central)
DOI: DOI:10.1186/1423-0127-20-74   (Journal Full-text)


BACKGROUND: Intestinal polyps may further develop into colon cancer; the pathogenesis is not clear. The p53 gene is an important anti-cancer gene in the body, which is suppressed in cancer. The ubiquitin E3 ligase A20 (A20) plays a role in regulating the activities of epithelial cells. This study was designed to investigate the role of the colon polyp epithelium-derived A20 in the pathogenesis of colon cancer.
RESULTS: Eighty-eight colon cancer patients and 136 colon polyp patients were recruited into this study. Human colon cancer tissue, the epithelium of adenomas polyp and hyperplastic polyp showed high levels of A20, which had a positive correlation with the cancerous tendency of colon polyps. The levels of A20 were much higher in the adenomas and hyperplastic polyps than that in the inflammatory polyps; the latter showed less cancerous tendency. A20 bound p53 to form complexes in colon cancer tissue and colon polyps. Over expression of A20 suppresses P53 protein levels in the HEK293 cells.
CONCLUSIONS: A20 may play an important role in the cancerous tendency of colon polyposis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
colon cancer  IEP 151347624mRNA and protein:increased expression:colon (human)RGD 
colon cancer  ISOTNFAIP3 (Homo sapiens)151347624; 151347624mRNA and protein:increased expression:colon (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tnfaip3  (TNF alpha induced protein 3)

Genes (Mus musculus)
Tnfaip3  (tumor necrosis factor, alpha-induced protein 3)

Genes (Homo sapiens)
TNFAIP3  (TNF alpha induced protein 3)


Additional Information