RGD Reference Report - Polymorphism of DNA repair gene xrcc1 and lung cancer risk. - Rat Genome Database

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Polymorphism of DNA repair gene xrcc1 and lung cancer risk.

Authors: Wang, Hong  Liu, Zhandi 
Citation: Wang H and Liu Z, Cell Biochem Biophys. 2014 Dec;70(3):1881-6. doi: 10.1007/s12013-014-0146-7.
RGD ID: 151347450
Pubmed: PMID:25038912   (View Abstract at PubMed)
DOI: DOI:10.1007/s12013-014-0146-7   (Journal Full-text)

The current large-scale meta-analysis was performed to reach a reliable conclusion on the association between X-ray repair cross-complementing 1 (xrcc1) rs1799782 and the development of lung cancer. Studies that investigated the association between rs1799782 and lung cancer risk were identified by searching PubMed. We calculated odds ratio (OR) with corresponding 95 % confidence interval (CI) for Trp/Trp vs Arg/Arg, Trp/Trp + Arg/Trp vs Arg/Arg, and Trp/Trp vs Arg/Trp + Arg/Arg contrast models. Combining all 25 studies, we yielded three summary ORs: 1.07 (95 % CI 0.92-1.23) for Trp/Trp vs Arg/Arg, 0.93 (95 % CI 0.87-1.00) for Trp/Trp + Arg/Trp vs Arg/Arg, and 1.08 (95 % CI 0.94-1.25) for Trp/Trp vs Arg/Trp + Arg/Arg, suggesting rs1799782 was not associated with overall risk of lung cancer. Strikingly, a significantly deceased risk was found among Caucasian populations (Trp/Trp + Arg/Trp vs Arg/Arg, OR = 0.86, 95 % CI 0.76-0.97). This study confirms that xrcc1 rs1799782 may lower the risk of lung cancer among Caucasians.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
lung cancer susceptibilityIAGP 151347450DNA:missense mutation:exon 10: p.R399Q (rs25487) (human)RGD 
lung cancer susceptibilityISOXRCC1 (Homo sapiens)151347450; 151347450DNA:missense mutation:exon 10: p.R399Q (rs25487) (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Neoplasm of the lung susceptibilityIAGP 151347450DNA:missense mutation:exon 10: p.R399Q (rs25487) (human)RGD 
Objects Annotated

Genes (Rattus norvegicus)
Xrcc1  (X-ray repair cross complementing 1)

Genes (Mus musculus)
Xrcc1  (X-ray repair complementing defective repair in Chinese hamster cells 1)

Genes (Homo sapiens)
XRCC1  (X-ray repair cross complementing 1)


Additional Information