RGD Reference Report - Dopamine receptor D1/D5 gene expression in the medial prefrontal cortex predicts impulsive choice in rats. - Rat Genome Database

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Dopamine receptor D1/D5 gene expression in the medial prefrontal cortex predicts impulsive choice in rats.

Authors: Loos, Maarten  Pattij, Tommy  Janssen, Mieke C W  Counotte, Danielle S  Schoffelmeer, Anton N M  Smit, August B  Spijker, Sabine  van Gaalen, Marcel M 
Citation: Loos M, etal., Cereb Cortex. 2010 May;20(5):1064-70. doi: 10.1093/cercor/bhp167. Epub 2009 Aug 18.
RGD ID: 15092092
Pubmed: PMID:19690230   (View Abstract at PubMed)
DOI: DOI:10.1093/cercor/bhp167   (Journal Full-text)

A neuropsychological hallmark of attention deficit/hyperactivity disorder (ADHD) is the reduced ability to tolerate delay of reinforcement, leading to impulsive choice. Genetic association studies have implicated several genes involved in dopaminergic neurotransmission in ADHD. In this study, we investigated whether differences in the expression level of these dopamine-related genes of rats predict the individual level of impulsive choice. Among all frontostriatal brain regions tested, only in the medial prefrontal cortex (mPFC), we observed significant positive correlations between impulsive choice and transcript levels of the dopamine receptor D(1), the dopamine receptor D(5) and calcyon. Local mPFC infusions of the D(1)/D(5) receptor antagonist SCH 23390 and agonist SKF 38393 resulted in increased impulsive choice, in agreement with the idea that endogenous receptor D(1)/D(5) stimulation in the mPFC promotes the choice of large delayed rewards. Together, these data indicate that this class of dopamine receptors in the mPFC plays a pivotal role in impulsive choice, and aberrancies thereof might contribute to ADHD symptomatology.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Objects Annotated

Genes (Rattus norvegicus)
Caly  (calcyon neuron-specific vesicular protein)

Genes (Mus musculus)
Caly  (calcyon neuron-specific vesicular protein)

Genes (Homo sapiens)
CALY  (calcyon neuron specific vesicular protein)


Additional Information