RGD Reference Report - Identification of a nuclear receptor for bile acids. - Rat Genome Database

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Identification of a nuclear receptor for bile acids.

Authors: Makishima, M  Okamoto, A Y  Repa, J J  Tu, H  Learned, R M  Luk, A  Hull, M V  Lustig, K D  Mangelsdorf, D J  Shan, B 
Citation: Makishima M, etal., Science. 1999 May 21;284(5418):1362-5. doi: 10.1126/science.284.5418.1362.
RGD ID: 15090836
Pubmed: (View Article at PubMed) PMID:10334992
DOI: Full-text: DOI:10.1126/science.284.5418.1362

Bile acids are essential for the solubilization and transport of dietary lipids and are the major products of cholesterol catabolism. Results presented here show that bile acids are physiological ligands for the farnesoid X receptor (FXR), an orphan nuclear receptor. When bound to bile acids, FXR repressed transcription of the gene encoding cholesterol 7alpha-hydroxylase, which is the rate-limiting enzyme in bile acid synthesis, and activated the gene encoding intestinal bile acid-binding protein, which is a candidate bile acid transporter. These results demonstrate a mechanism by which bile acids transcriptionally regulate their biosynthesis and enterohepatic transport.

Gene Ontology Annotations    

Biological Process

Cellular Component

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Nr1h4  (nuclear receptor subfamily 1, group H, member 4)

Additional Information