RGD Reference Report - SOCS1 methylation in patients with newly diagnosed acute myeloid leukemia. - Rat Genome Database

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SOCS1 methylation in patients with newly diagnosed acute myeloid leukemia.

Authors: Chen, Chien-Yuan  Tsay, Woei  Tang, Jih-Luh  Shen, Hwei-Ling  Lin, Shu-Wha  Huang, Sheng-Yi  Yao, Ming  Chen, Yao-Chang  Shen, Ming-Ching  Wang, Chiu-Hwa  Tien, Hwei-Fang 
Citation: Chen CY, etal., Genes Chromosomes Cancer. 2003 Jul;37(3):300-5. doi: 10.1002/gcc.10222.
RGD ID: 150573811
Pubmed: PMID:12759928   (View Abstract at PubMed)
DOI: DOI:10.1002/gcc.10222   (Journal Full-text)

The proliferation and differentiation of hematopoietic precursor cells depend on various cytokines. The suppressor of cytokine signaling-1 (SOCS1) down-regulates Janus kinases/signal transducers and activators of transcription (JAK/STAT) pathway activity and inhibits the biological effects of cytokines. SOCS1 has been shown to have tumor-suppressor activity, and methylation of this gene, resulting in transcriptional silencing, has been found in 65% of hepatocellular carcinoma and has been suggested to play an important role in the development of the cancer. The methylation status of the SOCS1 gene in acute myeloid leukemia (AML) has not been reported before. In this study, we analyzed SOCS1 methylation in 89 patients with newly diagnosed AML and correlated the result with immunophenotypes, cytogenetics, clinical features, and treatment outcome. SOCS1 methylation was found in the leukemic cells from 53 patients (60%). Thirteen (76%) of the 17 patients with t(15;17) had SOCS1 methylation, whereas this gene was methylated in only one (11%) of the nine patients with t(8;21). The frequencies of SOCS1 methylation among various cytogenetic subgroups differed significantly (P = 0.014). Other clinical and laboratory parameters and the disease-free survival and overall survival were similar between patients with and without SOCS1 methylation. In conclusion, SOCS1 methylation occurs in more than half of AML cases, correlates with cytogenetic abnormalities, and may play an important role in the development of subsets of AML.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
acute myeloid leukemia  IDA 150573811DNA:hypermethylation: :RGD 
acute myeloid leukemia  ISOSOCS1 (Homo sapiens)150573811; 150573811DNA:hypermethylation: :RGD 

Objects Annotated

Genes (Rattus norvegicus)
Socs1  (suppressor of cytokine signaling 1)

Genes (Mus musculus)
Socs1  (suppressor of cytokine signaling 1)

Genes (Homo sapiens)
SOCS1  (suppressor of cytokine signaling 1)


Additional Information