RGD Reference Report - Investigating the association between XRCC1 gene polymorphisms and susceptibility to gastric cancer. - Rat Genome Database

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Investigating the association between XRCC1 gene polymorphisms and susceptibility to gastric cancer.

Authors: Chen, S  Zhu, X C  Liu, Y L  Wang, C  Zhang, K G 
Citation: Chen S, etal., Genet Mol Res. 2016 Sep 9;15(3). pii: gmr8342. doi: 10.4238/gmr.15038342.
RGD ID: 150530630
Pubmed: PMID:27706710   (View Abstract at PubMed)
DOI: DOI:10.4238/gmr.15038342   (Journal Full-text)

We carried out a hospital-based case-control study to investigate the role of XRCC1 gene Arg399Gln, Arg280His, and Arg194Trp polymorphisms in susceptibility to gastric cancer. A total of 214 gastric cancer patients and 247 control subjects were recruited between March 2013 and March 2015, and polymorphism genotype frequencies were determined by polymerase chain reaction-restriction fragment length polymorphism. Using the chi-square test, we detected statistically significant differences in age (chi-square = 22.25, P < 0.001), gender (chi-square = 6.74, P = 0.01), and family history of cancer (chi-square = 4.73, P = 0.03) between the case and control groups. Logistic regression analysis revealed that the XRCC1 Arg194Trp TT genotype conferred increased susceptibility to gastric cancer compared to the CC genotype [odds ratio (OR) = 2.38, 95% confidence interval (CI) = 1.28-4.49]. Moreover, individuals carrying the T allele of this variant were found to be at moderately increased risk of this disease (OR = 1.56, 95%CI = 1.16-2.09). However, the XRCC1 Arg399Gln and Arg280His polymorphisms were shown to have no influence on the development of gastric cancer. In conclusion, we suggest that the XRCC1 gene Arg194Trp polymorphism is associated with gastric cancer susceptibility in the Chinese population.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
stomach cancer susceptibilityIAGP 150530630DNA:SNP:: p.R194W (human)RGD 
stomach cancer susceptibilityISOXRCC1 (Homo sapiens)150530630; 150530630DNA:SNP:: p.R194W (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Neoplasm of the stomach susceptibilityIAGP 150530630DNA:SNP:: p.R194W (human)RGD 
Objects Annotated

Genes (Rattus norvegicus)
Xrcc1  (X-ray repair cross complementing 1)

Genes (Mus musculus)
Xrcc1  (X-ray repair complementing defective repair in Chinese hamster cells 1)

Genes (Homo sapiens)
XRCC1  (X-ray repair cross complementing 1)


Additional Information