RGD Reference Report - Biomarkers of the early response to treatment of visceral leishmaniasis: A prospective cohort study. - Rat Genome Database

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Biomarkers of the early response to treatment of visceral leishmaniasis: A prospective cohort study.

Authors: S Lima, Simone  Cavalcante Braz, Débora  Costa Silva, Vladimir  J C Farias, Teresinha  Zacarias, Danielle Alves  da Silva, Jailthon Carlos  Costa, Carlos Henrique Nery  Costa, Dorcas Lamounier 
Citation: S Lima S, etal., Parasite Immunol. 2021 Jan;43(1):e12797. doi: 10.1111/pim.12797. Epub 2020 Oct 20.
RGD ID: 150523791
Pubmed: PMID:32984951   (View Abstract at PubMed)
DOI: DOI:10.1111/pim.12797   (Journal Full-text)


BACKGROUND: Early biomarkers of the response to treatment are lacking and may help to reduce mortality by the vector-borne disease visceral leishmaniasis (VL).
METHODS: A prospective cohort study was conducted to investigate plasma cytokines and clinical laboratory data as biomarkers of the early response to specific treatment for VL in 36 patients.
RESULTS: The mean interleukin 6 (IL-6) concentration on the 7th day was 2.3% of the pre-treatment concentration, interleukin 10 (IL-10) was 8.0%, and interleukin 8 (IL-8) was 8.2%. On the 7th day, IL-10 was below half of the pre-treatment concentration in 100.0%, IL-8 in 95.5% and IL-6 in 90.9%. The spleen and liver sizes, haemoglobin, interleukin 1 beta (IL-1β) and tumour necrosis factor alpha (TNF-α) showed a slower recovery. Fever disappeared in 91% on the 7th day, 69.4% had a normal white cell count, and 77.8% had a normal platelet value by this time.
CONCLUSIONS: The plasma cytokines IL-6, IL-10 and IL-8 were demonstrated to be excellent markers of the early response to VL treatment and if tested before the 7th day, will likely prove to be better than fever measurement.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CXCL8Humanvisceral leishmaniasis treatmentIDA  RGD 
Cxcl15Mousevisceral leishmaniasis treatmentISOCXCL8 (Homo sapiens) RGD 

Objects Annotated

Genes (Mus musculus)
Cxcl15  (C-X-C motif chemokine ligand 15)

Genes (Homo sapiens)
CXCL8  (C-X-C motif chemokine ligand 8)


Additional Information