RGD Reference Report - Evaluation of interleukin-8 -251 t/a polymorphisms in visceral leishmaniasis. - Rat Genome Database

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Evaluation of interleukin-8 -251 t/a polymorphisms in visceral leishmaniasis.

Authors: Hajilooi, Mehrdad  Abasi, Mohammad  Bazmani, Ahad  Ahmadi, Alireza  Matini, Mohammad  Solgi, Ghasem  Sardarian, Khosro 
Citation: Hajilooi M, etal., J Res Health Sci. 2015 Winter;15(1):59-61.
RGD ID: 150523789
Pubmed: PMID:25821028   (View Abstract at PubMed)


BACKGROUND: Interleukin (IL)-8 plays important roles in the recruitment and activation of immune cells during visceral leishmaniasis (VL). Genetic variations in IL-8 modulate the expression of IL-8 protein and may be associated with VL. This study aimed to evaluate polymorphisms at the IL-8 -251 position in VL patients.
METHODS: This cross-sectional study was performed on three groups: Leishmania-seropositive patients with clinical symptoms of VL (n = 91), seropositive patients without clinical symptoms (n = 104), and healthy controls (n = 110). Polymorphisms at the IL-8-251 position were analyzed using allele-specific polymerase chain reaction (PCR). Anti-Leishmania antibody titers were assessed by immunofluorescence.
RESULTS: IL-8-251 polymorphism was significantly associated with VL (P<0.002). The IL-8-251 T/T genotype was significantly higher in group 1 than in groups 2 and 3 (P<0.002). The validity of the data was analyzed using Hardy-Weinberg equilibrium and one-way analysis of variance (ANOVA), as well as χ2 tests.
CONCLUSIONS: IL-8-251 polymorphism was significantly associated with impaired immune responses in VL and might be considered a risk factor for disease development.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
visceral leishmaniasis susceptibilityIAGP 150523789DNA:SNP:promoter:g.-251A>T (human)RGD 
visceral leishmaniasis susceptibilityISOCXCL8 (Homo sapiens)150523789DNA:SNP:promoter:g.-251A>T (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Invasive parasitic infection susceptibilityIAGP 150523789DNA:SNP:promoter:g.-251A>TRGD 
Objects Annotated

Genes (Mus musculus)
Cxcl15  (C-X-C motif chemokine ligand 15)

Genes (Homo sapiens)
CXCL8  (C-X-C motif chemokine ligand 8)


Additional Information