RGD Reference Report - Long non-coding RNA LINC00978 promotes cell proliferation and tumorigenesis via regulating microRNA-497/NTRK3 axis in gastric cancer. - Rat Genome Database

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Long non-coding RNA LINC00978 promotes cell proliferation and tumorigenesis via regulating microRNA-497/NTRK3 axis in gastric cancer.

Authors: Bu, Ju-Yuan  Lv, Wei-Ze  Liao, Yi-Feng  Xiao, Xiao-Yu  Lv, Bao-Jun 
Citation: Bu JY, etal., Int J Biol Macromol. 2019 Feb 15;123:1106-1114. doi: 10.1016/j.ijbiomac.2018.11.162. Epub 2018 Nov 17.
RGD ID: 150519920
Pubmed: PMID:30452981   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ijbiomac.2018.11.162   (Journal Full-text)

Gastric cancer (GC) is the most common gastrointestinal malignancy in the digestive system. Recent studies have proven that long non-coding RNAs (lncRNAs) are closely related to tumor growth and metastasis. The study aimed to explore the effect of LINC00978 on GC cells proliferation and tumorigenesis. LINC00978 was up-regulated in GC tissues and cell lines. Up-regulation of LINC00978 was positively correlated with low survival rate. LINC00978 silence inhibited proliferation, metastasis, and promoted apoptosis in BGC-823 cells. Additionally, LINC00978 functioned as competing endogenous RNA to inhibit miR-497 expression. Further, NTRK3 was confirmed as a target gene of miR-497. Up-regulation of NTRK3 was found in GC tissues, and the positive correlation was presented between LINC00978 and NTRK3. Further, LINC00978 promoted cell proliferation and tumor weight by regulation of NTRK3. These findings demonstrated that LINC00978 promoted cell proliferation and tumorigenesis by regulating miR-497/NTRK3 axis in GC.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NTRK3Humanstomach cancer amelioratesIMP  RGD 
Ntrk3Ratstomach cancer amelioratesISONTRK3 (Homo sapiens) RGD 
Ntrk3Mousestomach cancer amelioratesISONTRK3 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ntrk3  (neurotrophic receptor tyrosine kinase 3)

Genes (Mus musculus)
Ntrk3  (neurotrophic tyrosine kinase, receptor, type 3)

Genes (Homo sapiens)
NTRK3  (neurotrophic receptor tyrosine kinase 3)


Additional Information