RGD Reference Report - Discoidin domain receptor inhibition reduces neuropathology and attenuates inflammation in neurodegeneration models. - Rat Genome Database

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Discoidin domain receptor inhibition reduces neuropathology and attenuates inflammation in neurodegeneration models.

Authors: Hebron, Michaeline  Peyton, Margo  Liu, Xiaoguang  Gao, Xiaokong  Wang, Ruochong  Lonskaya, Irina  Moussa, Charbel E-H 
Citation: Hebron M, etal., J Neuroimmunol. 2017 Oct 15;311:1-9. doi: 10.1016/j.jneuroim.2017.07.009. Epub 2017 Aug 12.
RGD ID: 150519888
Pubmed: PMID:28863860   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jneuroim.2017.07.009   (Journal Full-text)

The role of cell surface tyrosine kinase collagen-activated receptors known as discoidin domain receptors (DDRs) is unknown in neurodegenerative diseases. We detect up-regulation in DDRs level in post-mortem Alzheimer and Parkinson brains. Lentiviral shRNA knockdown of DDR1 and DDR2 reduces the levels of α-synuclein, tau, and β-amyloid and prevents cell loss in vivo and in vitro. DDR1 and DDR2 knockdown alters brain immunity and significantly reduces the level of triggering receptor expressed on myeloid cells (TREM)-2 and microglia. These studies suggest that DDR1 and DDR2 inhibition is a potential target to clear neurotoxic proteins and reduce inflammation in neurodegeneration.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Alzheimer's disease treatmentISODdr1 (Mus musculus)150519888; 150519888 RGD 
Alzheimer's disease treatmentIMP 150519888 RGD 
Parkinson's disease treatmentISODdr2 (Mus musculus)150519888; 150519888 RGD 
Parkinson's disease treatmentIMP 150519888 RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
positive regulation of cellular process  IMP 150519888neuroblastoma cell deathRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ddr1  (discoidin domain receptor tyrosine kinase 1)
Ddr2  (discoidin domain receptor tyrosine kinase 2)

Genes (Mus musculus)
Ddr1  (discoidin domain receptor family, member 1)
Ddr2  (discoidin domain receptor family, member 2)

Genes (Homo sapiens)
DDR1  (discoidin domain receptor tyrosine kinase 1)
DDR2  (discoidin domain receptor tyrosine kinase 2)


Additional Information