RGD Reference Report - Upregulation of discoidin domain receptor 2 in nasopharyngeal carcinoma. - Rat Genome Database

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Upregulation of discoidin domain receptor 2 in nasopharyngeal carcinoma.

Authors: Chua, Huey-Huey  Yeh, Te-Huei  Wang, Ying-Piao  Huang, Yu-Tzu  Sheen, Tzung-Shiahn  Lo, You-Chang  Chou, Ya-Ching  Tsai, Ching-Hwa 
Citation: Chua HH, etal., Head Neck. 2008 Apr;30(4):427-36. doi: 10.1002/hed.20724.
RGD ID: 150429715
Pubmed: PMID:18023033   (View Abstract at PubMed)
DOI: DOI:10.1002/hed.20724   (Journal Full-text)


BACKGROUND: Nasopharyngeal carcinoma (NPC) is associated with Epstein-Barr virus (EBV) and has high metastatic potential. Discoidin domain receptors (DDR1, DDR2) are receptor-type tyrosine kinases activated by collagen. Their ability to induce expression of matrix metalloproteinase is related with tumor invasion. Therefore, we aim to investigate DDRs gene expression and its regulation in NPC.
METHODS AND RESULTS: By use of real-time quantitative polymerase chain reaction (Q-PCR), DDR2 gene expression but not DDR1 was significantly higher in primary and metastatic NPC. DDR2 was predominantly distributed in NPC tumor cells rather than in infiltrating lymphocytes. EBV Z-transactivator (Zta) transfection may distinctly elevate DDR2 level. Furthermore, data from reporter assay indicate that Zta could transactivate DDR2 promoter activity, suggesting the possible upregulation mechanism.
CONCLUSION: DDR2 was differentially upregulated in NPC and modulated by EBV Zta protein. DDR2 may play a role in NPC invasion and serve as a diagnostic and therapeutic target.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
nasopharynx carcinoma  IEP 150429715mRNA:increased expression:epithelium of nasopharynxRGD 
nasopharynx carcinoma  ISODDR2 (Homo sapiens)150429715; 150429715mRNA:increased expression:epithelium of nasopharynxRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ddr2  (discoidin domain receptor tyrosine kinase 2)

Genes (Mus musculus)
Ddr2  (discoidin domain receptor family, member 2)

Genes (Homo sapiens)
DDR2  (discoidin domain receptor tyrosine kinase 2)


Additional Information