RGD Reference Report - Increased plasma interleukin-32 expression in patients with neuromyelitis optica. - Rat Genome Database

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Increased plasma interleukin-32 expression in patients with neuromyelitis optica.

Authors: Wang, Honghao  Wang, Kai  Wang, Conghui  Xu, Fangcheng  Qiu, Wei  Hu, Xueqiang 
Citation: Wang H, etal., J Clin Immunol. 2013 Apr;33(3):666-70. doi: 10.1007/s10875-012-9837-2. Epub 2012 Nov 21.
RGD ID: 150340728
Pubmed: PMID:23180362   (View Abstract at PubMed)
DOI: DOI:10.1007/s10875-012-9837-2   (Journal Full-text)


PURPOSE: Neuromyelitis optica (NMO) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). The pathogenesis of NMO remains unclear. IL-32 is emerging as a critical molecule in the pathophysiology of immune-mediated chronic inflammatory diseases. Whether IL-32 levels are elevated in NMO patients is unclear. We aimed to determine whether IL-32 levels are elevated in NMO patients and explore its relationship with IL-6, IL-17, and Expanded Disability Status Scale (EDSS) scores.
METHODS: Plasma IL-32α, IL-6 and IL-17A were measured by enzyme-linked immunosorbent assay in NMO (n = 26), MS (n = 23) and 22 healthy controls.
RESULTS: We found IL-32α levels were higher in NMO patients compared with MS (p = 0.020) and healthy controls (p = 0.00001). IL-32α levels were increased in MS patients compared with controls (p = 0.009). IL-32α positively correlated with IL-6 and IL-17A levels and EDSS scores in NMO patients.
CONCLUSIONS: In summary, plasma IL-32α levels are associated with inflammatory responses in NMO patients.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
multiple sclerosis  IEP 150340728protein:increased expression:blood plasma (human)RGD 
neuromyelitis optica exacerbatesIEP 150340728protein:increased expression:blood plasma (human)RGD 

Objects Annotated

Genes (Homo sapiens)
IL32  (interleukin 32)


Additional Information