RGD Reference Report - Interleukin-32 is highly expressed in lesions of hidradenitis suppurativa. - Rat Genome Database

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Interleukin-32 is highly expressed in lesions of hidradenitis suppurativa.

Authors: Thomi, R  Yerly, D  Yawalkar, N  Simon, D  Schlapbach, C  Hunger, R E 
Citation: Thomi R, etal., Br J Dermatol. 2017 Nov;177(5):1358-1366. doi: 10.1111/bjd.15458. Epub 2017 Sep 27.
RGD ID: 150340720
Pubmed: PMID:28301691   (View Abstract at PubMed)
DOI: DOI:10.1111/bjd.15458   (Journal Full-text)


BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. Its immunopathogenic mechanisms are still poorly understood. Previous studies demonstrated that the proinflammatory cytokine interleukin (IL)-32 is implicated in the pathogenesis of other inflammatory diseases.
OBJECTIVES: To investigate the tissue expression and systemic levels of IL-32, as well as its cellular sources, in patients with HS in comparison with healthy donors and patients with two other inflammatory skin diseases: psoriasis and atopic dermatitis (AD).
METHODS: Tissue samples were obtained from healthy skin and lesional HS, psoriatic and AD skin to analyse the expression of IL-32 by immunohistochemistry and semiquantitative real-time polymerase chain reaction. The cellular source of the cytokine was determined by double immunofluorescence staining. Serum from the four donor groups was used to measure systemic levels of IL-32 by enzyme-linked immunosorbent assay.
RESULTS: IL-32 was upregulated in patients with HS in both lesional skin and serum when compared with healthy donors and patients with AD or psoriasis. In HS, IL-32 was found to be expressed by natural killer cells, T cells, macrophages and dendritic cells in highly infiltrated areas of the dermis. High IL32 mRNA levels in lesional HS skin coincided with high amounts of T cells and macrophages. Additionally, IL32 mRNA levels in lesional HS skin correlate positively with interferon-γ and IL-17A and negatively with IL-13.
CONCLUSIONS: Our findings suggest that IL-32 is overexpressed in HS. Targeting IL-32 may therefore represent a new therapeutic option for the treatment of this recalcitrant disease.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
atopic dermatitis  IEP 150340720mRNA:splice variant:zone of skin (human)RGD 
hidradenitis suppurativa exacerbatesIEP 150340720mRNA more ...RGD 
psoriasis  IEP 150340720mRNA:splice variant:zone of skin (human)RGD 

Objects Annotated

Genes (Homo sapiens)
IL32  (interleukin 32)


Additional Information