RGD Reference Report - Cytokine profile in gingival crevicular fluid and plasma of patients with aggressive periodontitis. - Rat Genome Database

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Cytokine profile in gingival crevicular fluid and plasma of patients with aggressive periodontitis.

Authors: Zein Elabdeen, Hager R  Mustafa, Manal  Ali, Raouf  Bolstad, Anne Isine 
Citation: Zein Elabdeen HR, etal., Acta Odontol Scand. 2017 Nov;75(8):616-622. doi: 10.1080/00016357.2017.1372623. Epub 2017 Sep 3.
RGD ID: 14975264
Pubmed: (View Article at PubMed) PMID:28868949
DOI: Full-text: DOI:10.1080/00016357.2017.1372623


OBJECTIVE: This study aimed to determine the content of cytokines in gingival crevicular fluid (GCF) as well as in plasma of Sudanese patients with aggressive periodontitis (AgP) and healthy controls (HC).
MATERIALS AND METHODS: Nineteen AgP patients and 19 HC were included. The mean probing pocket depth and clinical attachment level of the GCF sampled sites in patients were both >=5 mm. The GCF and plasma levels of 27 cytokines were determined using 27-multiplex fluorescent bead-based immunoassays. Ratios were calculated among cytokines of the T-helper cell subsets Th1 and Th2. Descriptive statistics, the Mann-Whitney U-test and Spearman's rho rank correlation coefficient analysis were used.
RESULTS: Interferon-γ was the only cytokine found in significantly lower levels in GCF of patients compared with HC. Levels of interleukin (IL)-10, IL-13, IL-1Ra, monocyte chemoattractant protein-1 (MCP-1), regulated on activation normal T-cell expressed and secreted (RANTES), granulocyte-colony-stimulating factor (G-CSF), and granulocyte-macrophage-CSF (GM-CSF) were significantly lower in plasma of AgP compared with HC. The ratios of Th1:Th2 in GCF and Treg:Th17 in plasma were significantly lower in AgP.
CONCLUSIONS: The lower levels of cytokines detected systemically in plasma of AgP patients may have an impact on the immune response. The lower ratio of Th1:Th2 cytokines in GCF samples of AgP patients suggests a role for Th2 at the local site of disease.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Il10  (interleukin 10)

Genes (Mus musculus)
Il10  (interleukin 10)

Genes (Homo sapiens)
IL10  (interleukin 10)


Additional Information