RGD Reference Report - [Increased serum levels of soluble programmed death-1 (sPD-1) and sPD-ligand 1 in patients infected with Brucella]. - Rat Genome Database

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[Increased serum levels of soluble programmed death-1 (sPD-1) and sPD-ligand 1 in patients infected with Brucella].

Authors: Pang, Pan  Zhu, Yuejie  Jia, Bin  Yang, Yan  Hu, Jinwei  Zhang, Yuexin  Zhang, Fengbo  Ding, Jianbing 
Citation: Pang P, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016 Dec;32(12):1675-1678.
RGD ID: 14974260
Pubmed: PMID:27916101   (View Abstract at PubMed)

Objective To investigate the alterations of soluble molecule programmed death 1 (sPD-1) and soluble programmed death ligand 1 (sPD-L1), as well as related Th1 cytokines IFN-γ and Th2 cytokines IL-4 in patients infected with Brucella. Methods The study enrolled 56 patients infected with Brucella and 48 healthy controls. Serum sPD-1 and sPD-L1 were detected by ELISA and the levels of Th1/Th2 cytokines were measured with cytometric bead array (CBA). Among them, 37 patients received follow-up. Results Compared with the control group, the serum levels of sPD-1/sPD-L1 and IL-4 increased significantly, while the level of IFN-γ decreased significantly. In the 37 patients receiving follow-up after treatment, serum levels of sPD-1/sPD-L1 and IL-4 were remarkably lower than those in pretherapy, while the level of IFN-γ was obviously higher than that in pretherapy. Conclusion The increase of sPD-1 and sPD-L1 may be involved in the process of Brucella infection.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IFNGHumanbrucellosis treatmentIEP  RGD 
IfngRatbrucellosis treatmentISOIFNG (Homo sapiens) RGD 
IfngMousebrucellosis treatmentISOIFNG (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ifng  (interferon gamma)

Genes (Mus musculus)
Ifng  (interferon gamma)

Genes (Homo sapiens)
IFNG  (interferon gamma)


Additional Information