RGD Reference Report - Virulence of representative Japanese Francisella tularensis and immunologic consequences of infection in mice. - Rat Genome Database

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Virulence of representative Japanese Francisella tularensis and immunologic consequences of infection in mice.

Authors: Hotta, Akitoyo  Fujita, Osamu  Uda, Akihiko  Yamamoto, Yoshie  Sharma, Neekun  Tanabayashi, Kiyoshi  Yamada, Akio  Morikawa, Shigeru 
Citation: Hotta A, etal., Microbiol Immunol. 2016 Mar;60(3):168-76. doi: 10.1111/1348-0421.12363.
RGD ID: 14974256
Pubmed: PMID:26853540   (View Abstract at PubMed)
DOI: DOI:10.1111/1348-0421.12363   (Journal Full-text)

Francisella tularensis, which causes tularemia, is widely distributed in the Northern hemisphere. F. tularensis strains isolated in Japan are genetically unique from non-Japanese strains; however, their phenotypic properties have not been well studied. Thus, mice were infected with representative Japanese strains of F. tularensis and their virulence and mouse immune responses to them assessed. Of four representative Japanese strains, the Ebina, Jap and Tsuchiya strains were susceptible to H2 O2 and did not grow well intracellularly. Only Yama strain grew intracellularly and was lethal to mice. Infection with Yama strain resulted in drastic increases in IFN-γ, CD4 and CD8 double-positive T cells and Th1 cells (CD3, CD4 and Tim3-positive cells), and a decrease in the ratio of CD8-positive CD4-negative T cells in mice. C57BL/6J mice that survived infection produced IgM antibodies to LPS and IgG2c antibodies to 43, 19 and 17 kDa proteinase K-sensitive components. These data are valuable for understanding the phenotypic properties of F. tularensis in Japan.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IFNGHumantularemia  ISOIfng (Mus musculus)protein:increased expression:serumRGD 
IfngRattularemia  ISOIfng (Mus musculus)protein:increased expression:serumRGD 
IfngMousetularemia  IEP protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ifng  (interferon gamma)

Genes (Mus musculus)
Ifng  (interferon gamma)

Genes (Homo sapiens)
IFNG  (interferon gamma)


Additional Information