RGD Reference Report - Macrophage Activation Marker Soluble CD163 Associated with Fatal and Severe Ebola Virus Disease in Humans1. - Rat Genome Database

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Macrophage Activation Marker Soluble CD163 Associated with Fatal and Severe Ebola Virus Disease in Humans1.

Authors: McElroy, Anita K  Shrivastava-Ranjan, Punya  Harmon, Jessica R  Martines, Roosecelis B  Silva-Flannery, Luciana  Flietstra, Timothy D  Kraft, Colleen S  Mehta, Aneesh K  Lyon, G Marshall  Varkey, Jay B  Ribner, Bruce S  Nichol, Stuart T  Zaki, Sherif R  Spiropoulou, Christina F 
Citation: McElroy AK, etal., Emerg Infect Dis. 2019 Feb;25(2):290-298. doi: 10.3201/eid2502.181326.
RGD ID: 149735528
Pubmed: PMID:30666927   (View Abstract at PubMed)
PMCID: PMC6346465   (View Article at PubMed Central)
DOI: DOI:10.3201/eid2502.181326   (Journal Full-text)

Ebola virus disease (EVD) is associated with elevated cytokine levels, and hypercytokinemia is more pronounced in fatal cases. This type of hyperinflammatory state is reminiscent of 2 rheumatologic disorders known as macrophage activation syndrome and hemophagocytic lymphohistiocytosis, which are characterized by macrophage and T-cell activation. An evaluation of 2 cohorts of patients with EVD revealed that a marker of macrophage activation (sCD163) but not T-cell activation (sCD25) was associated with severe and fatal EVD. Furthermore, substantial immunoreactivity of host tissues to a CD163-specific antibody, predominantly in areas of extensive immunostaining for Ebola virus antigens, was observed in fatal cases. These data suggest that host macrophage activation contributes to EVD pathogenesis and that directed antiinflammatory therapies could be beneficial in the treatment of EVD.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CD163HumanEbola virus disease exacerbatesIEP protein:increased expression:blood plasma (human)RGD 
Cd163RatEbola virus disease exacerbatesISOCD163 (Homo sapiens)protein:increased expression:blood plasma (human)RGD 
Cd163MouseEbola virus disease exacerbatesISOCD163 (Homo sapiens)protein:increased expression:blood plasma (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd163  (CD163 molecule)

Genes (Mus musculus)
Cd163  (CD163 antigen)

Genes (Homo sapiens)
CD163  (CD163 molecule)


Additional Information