RGD Reference Report - HLA-DR-DQ alleles and HLA-DP alleles are independently associated with susceptibility to different stages of post-schistosomal hepatic fibrosis in the Chinese population. - Rat Genome Database

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HLA-DR-DQ alleles and HLA-DP alleles are independently associated with susceptibility to different stages of post-schistosomal hepatic fibrosis in the Chinese population.

Authors: Hirayama, K  Chen, H  Kikuchi, M  Yin, T  Gu, X  Liu, J  Zhang, S  Yuan, H 
Citation: Hirayama K, etal., Tissue Antigens. 1999 Mar;53(3):269-74.
RGD ID: 14694972
Pubmed: PMID:10203020   (View Abstract at PubMed)

Abstract: Evaluation of human leukocyte antigen (HLA) class I and class II genes was performed on patients from China with Schistosomiasis japonica. Patients were categorized as grade 0 (n=44), grade I (n=81), grade II (n=99), or grade III (n=6) based on increasing severity of hepatic fibrosis due to repeated Schistosoma japonicum infections. These results show that the HLA-DRB1*1101-DQA1*0501-DQB1*0301 (Pc<0.02) and HLA-DRB1*1501-DRB5*0101 (Pc<0.02) haplotypes are associated with protection and susceptibility to grade I fibrosis, respectively, and that the HLA-DPA1*0103 -DPB1*0201 haplotype (Pc<0.02) is associated with protection from both grade II and III severe fibrosis. There was no association between HLA-B DNA haplotypes and the disease. These findings indicate that the HLA-class II molecules play a role in preventing or promoting fibrotic liver change after deposition with Schistosome eggs. Moreover, a tendency was observed within the HLA class II genes for the HLA-DR-DQ alleles to be associated with protection against early changes in liver fibrosis, whereas HLA-DP alleles were associated with protection from the late phase of fibrosis or severe hepatosplenic schistosomiasis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
H2-PaMouseliver cirrhosis severityISORGD:1605730DAN:polymorphism: :RGD 
HLA-DPA1Humanliver cirrhosis severityIAGP DAN:polymorphism: :RGD 
RT1-HaRatliver cirrhosis severityISORGD:1605730DAN:polymorphism: :RGD 

Objects Annotated

Genes (Rattus norvegicus)
RT1-Ha  (RT1 class II, locus Ha)

Genes (Mus musculus)
H2-Pa  (histocompatibility 2, P region alpha locus)

Genes (Homo sapiens)
HLA-DPA1  (major histocompatibility complex, class II, DP alpha 1)


Additional Information