RGD Reference Report - Protective effects of HLA-DPA1/DPB1 variants against Hepatitis B virus infection in an Indonesian population. - Rat Genome Database

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Protective effects of HLA-DPA1/DPB1 variants against Hepatitis B virus infection in an Indonesian population.

Authors: Wasityastuti, Widya  Yano, Yoshihiko  Ratnasari, Neneng  Triyono, Teguh  Triwikatmani, Catharina  Indrarti, Fahmi  Heriyanto, Didik Setyo  Yamani, Laura Navika  Liang, Yujiao  Utsumi, Takako  Hayashi, Yoshitake 
Citation: Wasityastuti W, etal., Infect Genet Evol. 2016 Jul;41:177-184. doi: 10.1016/j.meegid.2016.03.034. Epub 2016 Apr 2.
RGD ID: 14694816
Pubmed: PMID:27051043   (View Abstract at PubMed)
DOI: DOI:10.1016/j.meegid.2016.03.034   (Journal Full-text)

Human leukocyte antigen (HLA) DPA1/DPB1 variants have been reported to influence Hepatitis B virus (HBV) infection. HLA-DPA1/DPB1 plays a pivotal role in antigen presentation to CD4(+) helper T cells and influences the outcome of HBV infection. To investigate the influence of HLA-DP variants on the outcome of HBV infection in an Indonesian population where it has the third-highest prevalence of HBV infection worldwide, we performed a case-control study of 686 participants, including patients with HBV-related advanced or nonadvanced liver disease, patients with spontaneously resolved HBV, and healthy controls. Single-nucleotide polymorphisms in HLA-DPA1 (rs3077) and HLA-DPB1 (rs3135021, rs9277535, and rs228388) were genotyped using real-time TaqMan® genotyping assays. Because rs2281388 deviated from Hardy-Weinberg equilibrium, it was excluded from subsequent analyses. The results of logistic regression analyses showed that the HLA-DPB1 rs9277535 variants were associated with a reduced risk of persistent HBV infection (odds ratio [OR] 0.70, 95% confidence interval [95% CI] 0.52-0.96, P=0.026, additive genetic model; OR 0.60, 95% CI 0.38-0.96, P=0.033, dominant genetic model). The HLA-DPA1 rs3077 variant was associated with a protective effect increasing the spontaneously resolved HBV infection (OR 0.64, 95% CI 0.41-0.98, P=0.039, dominant genetic model). By contrast, the HLA-DPB1 rs3135021 variant was not associated with the outcome of HBV infection, including susceptibility, spontaneously resolved, or disease progression. Combinations of haplotype markers were also associated with HBV susceptibility (CA for rs3077-rs9277535, OR 0.57, 95% CI 0.36-0.92, P=0.021; GA for rs3135021-rs9277535, OR 0.56, 95% CI 0.36-0.86, P=0.0087). In conclusion, these findings confirm that HLA-DPA1/DPB1 variants were associated with the outcomes of HBV infection in an Indonesian population.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HLA-DPB1HumanChronic Hepatitis B susceptibilityIAGP DNA:SNP: :rs33054861(human)RGD 
H2-PaMousehepatitis B disease_progressionISORGD:1605730DNA:SNP: :rs3077(human)RGD 
HLA-DPA1Humanhepatitis B disease_progressionIAGP DNA:SNP: :rs3077(human)RGD 
HLA-DPB1Humanhepatitis B susceptibilityIAGP DNA:SNP: :rs9277535(human)RGD 
RT1-HaRathepatitis B disease_progressionISORGD:1605730DNA:SNP: :rs3077(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
RT1-Ha  (RT1 class II, locus Ha)

Genes (Mus musculus)
H2-Pa  (histocompatibility 2, P region alpha locus)

Genes (Homo sapiens)
HLA-DPA1  (major histocompatibility complex, class II, DP alpha 1)
HLA-DPB1  (major histocompatibility complex, class II, DP beta 1)


Additional Information