RGD Reference Report - Calcium-binding protein, spermatid-specific 1 is expressed in human salivary glands and contains an anti-inflammatory motif. - Rat Genome Database

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Calcium-binding protein, spermatid-specific 1 is expressed in human salivary glands and contains an anti-inflammatory motif.

Authors: St Laurent, Chris D  St Laurent, Katherine E  Mathison, Ron D  Befus, A Dean 
Citation: St Laurent CD, etal., Am J Physiol Regul Integr Comp Physiol. 2015 Apr 1;308(7):R569-75. doi: 10.1152/ajpregu.00153.2014. Epub 2015 Jan 28.
RGD ID: 14400306
Pubmed: PMID:25632019   (View Abstract at PubMed)
PMCID: PMC4386001   (View Article at PubMed Central)
DOI: DOI:10.1152/ajpregu.00153.2014   (Journal Full-text)

Salivary glands are involved in the production and exocrine and endocrine secretion of biologically active proteins, polypeptides, and hormones involved in growth and differentiation, homeostasis, and digestion. We have previously studied the prohormone submandibular rat 1 (SMR1), product of the Vcsa1 gene, which is highly expressed in the testes and salivary glands of rats, and can be cleaved to produce polypeptides with analgesic, erectile function, and anti-inflammatory activities. Humans lack the Vcsa1 gene, but homologous sequences and functions for analgesia and erectile function exist in the human genes Prol1, SMR3a, and SMR3b located on the human chromosomal region close to where Vcsa1 lies in the rat. Here we show the human protein calcium-binding protein spermatid-specific 1 (CABS1) contains a similar sequence to the anti-inflammatory sequence in rat SMR1, thus CABS1 may be another human gene with homologous function to Vcsa1. Using Western blot and PCR, we discovered that the human protein CABS1, previously thought to only be expressed in the testes, is also expressed in the salivary glands and lung, in a tissue-specific manner. Peptides derived from CABS1 were tested in an in vivo mouse model of lipopolysaccharide (LPS)-induced neutrophilia and an ex vivo rat model of antigen-induced intestinal anaphylaxis and significantly reduced both neutrophil accumulation in bronchoalveolar lavage fluid and antigen-induced ileal contractions, respectively. Thus human CABS1 has a peptide motif homologous to the anti-inflammatory peptide sequence of rat SMR1. Whether this similarity of CABS1 extends to the neuroendocrine regulation of the anti-inflammatory activity seen for SMR1 remains to be determined.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CABS1HumanAnaphylaxis treatmentIDA  RGD 
Cabs1RatAnaphylaxis treatmentISOCABS1 (Homo sapiens) RGD 
Cabs1MouseAnaphylaxis treatmentISOCABS1 (Homo sapiens) RGD 
CABS1HumanInflammation treatmentIDA  RGD 
Cabs1RatInflammation treatmentISOCABS1 (Homo sapiens) RGD 
Cabs1MouseInflammation treatmentISOCABS1 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cabs1  (calcium binding protein, spermatid associated 1)

Genes (Mus musculus)
Cabs1  (calcium binding protein, spermatid specific 1)

Genes (Homo sapiens)
CABS1  (calcium binding protein, spermatid associated 1)


Additional Information