RGD Reference Report - Tryptophan-niacin metabolism in rat with puromycin aminonucleoside-induced nephrosis. - Rat Genome Database

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Tryptophan-niacin metabolism in rat with puromycin aminonucleoside-induced nephrosis.

Authors: Egashira, Yukari  Nagaki, Shin  Sanada, Hiroo 
Citation: Egashira Y, etal., Int J Vitam Nutr Res. 2006 Jan;76(1):28-33. doi: 10.1024/0300-9831.76.1.28.
RGD ID: 13831123
Pubmed: PMID:16711654   (View Abstract at PubMed)
DOI: DOI:10.1024/0300-9831.76.1.28   (Journal Full-text)

We investigated the change of tryptophan-niacin metabolism in rats with puromycin aminonucleoside PAN-induced nephrosis, the mechanisms responsible for their change of urinary excretion of nicotinamide and its metabolites, and the role of the kidney in tryptophan-niacin conversion. PAN-treated rats were intraperitoneally injected once with a 1.0% (w/v) solution of PAN at a dose of 100 mg/kg body weight. The collection of 24-hour urine was conducted 8 days after PAN injection. Daily urinary excretion of nicotinamide and its metabolites, liver and blood NAD, and key enzyme activities of tryptophan-niacin metabolism were determined. In PAN-treated rats, the sum of urinary excretion of nicotinamide and its metabolites was significantly lower compared with controls. The kidney alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) activity in the PAN-treated group was significantly decreased by 50%, compared with the control group. Although kidney ACMSD activity was reduced, the conversion of tryptophan to niacin tended to be lower in the PAN-treated rats. A decrease in urinary excretion of niacin and the conversion of tryptophan to niacin in nephrotic rats may contribute to a low level of blood tryptophan. The role of kidney ACMSD activity may be minimal concerning tryptophan-niacin conversion under this experimental condition.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  

Objects Annotated

Genes (Rattus norvegicus)
Acmsd  (aminocarboxymuconate semialdehyde decarboxylase)

Genes (Mus musculus)
Acmsd  (amino carboxymuconate semialdehyde decarboxylase)

Genes (Homo sapiens)
ACMSD  (aminocarboxymuconate semialdehyde decarboxylase)


Additional Information