RGD Reference Report - Mitochondrial coupling factor 6 as a potent endogenous vasoconstrictor. - Rat Genome Database

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Mitochondrial coupling factor 6 as a potent endogenous vasoconstrictor.

Authors: Osanai, T  Tanaka, M  Kamada, T  Nakano, T  Takahashi, K  Okada, S  Sirato, K  Magota, K  Kodama, S  Okumura, K 
Citation: Osanai T, etal., J Clin Invest. 2001 Oct;108(7):1023-30. doi: 10.1172/JCI11076.
RGD ID: 13800911
Pubmed: PMID:11581303   (View Abstract at PubMed)
PMCID: PMC200946   (View Article at PubMed Central)
DOI: DOI:10.1172/JCI11076   (Journal Full-text)

We demonstrated recently that coupling factor 6, an essential component of the energy-transducing stalk of mitochondrial ATP synthase, suppresses the synthesis of prostacyclin in vascular endothelial cells. Here, we tested the hypothesis that coupling factor 6 is present on the cell surface and is involved in the regulation of systemic circulation. This peptide is present on the surface of CRL-2222 vascular endothelial cells and is released by these cells into the medium. In vivo, the peptide circulates in the vascular system of the rat, and its gene expression and plasma concentration are higher in spontaneously hypertensive rats (SHRs) than in normotensive controls. Elevation of blood pressure with norepinephrine did not affect the plasma concentration of coupling factor 6. Intravenous injection of recombinant peptide increased blood pressure, apparently by suppressing prostacyclin synthesis, whereas a specific Ab to coupling factor 6 decreased systemic blood pressure concomitantly with an increase in plasma prostacyclin. Interestingly, the antibody's hypotensive effect could be abolished by treating with the cyclooxygenase inhibitor indomethacin. These findings indicate that mitochondrial coupling factor 6 functions as a potent endogenous vasoconstrictor in the fashion of a circulating hormone and may suggest a new mechanism for hypertension.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Atp5pfRatnegative regulation of prostaglandin secretion  IDA  RGD 
Atp5pfRatpositive regulation of blood pressure  IDA  RGD 
Atp5pfRatpositive regulation of blood pressure  IMP  RGD 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Atp5pfRatcell surface  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Atp5pf  (ATP synthase peripheral stalk subunit F6)


Additional Information