RGD Reference Report - Bcl-2 and ß1-integrin predict survival in a tissue microarray of small cell lung cancer. - Rat Genome Database

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Bcl-2 and ß1-integrin predict survival in a tissue microarray of small cell lung cancer.

Authors: Lawson, M H  Cummings, N M  Rassl, D M  Vowler, S L  Wickens, M  Howat, W J  Brenton, J D  Murphy, G  Rintoul, R C 
Citation: Lawson MH, etal., Br J Cancer. 2010 Nov 23;103(11):1710-5. doi: 10.1038/sj.bjc.6605950. Epub 2010 Nov 9.
RGD ID: 13792831
Pubmed: PMID:21063403   (View Abstract at PubMed)
PMCID: PMC2994222   (View Article at PubMed Central)
DOI: DOI:10.1038/sj.bjc.6605950   (Journal Full-text)


INTRODUCTION: Survival in small cell lung cancer (SCLC) is limited by the development of chemoresistance. Factors associated with chemoresistance in vitro have been difficult to validate in vivo. Both Bcl-2 and ß(1)-integrin have been identified as in vitro chemoresistance factors in SCLC but their importance in patients remains uncertain. Tissue microarrays (TMAs) are useful to validate biomarkers but no large TMA exists for SCLC. We designed an SCLC TMA to study potential biomarkers of prognosis and then used it to clarify the role of both Bcl-2 and ß(1)-integrin in SCLC.
METHODS: A TMA was constructed consisting of 184 cases of SCLC and stained for expression of Bcl-2 and ß(1)-integrin. The slides were scored and the role of the proteins in survival was determined using Cox regression analysis. A meta-analysis of the role of Bcl-2 expression in SCLC prognosis was performed based on published results.
RESULTS: Both proteins were expressed at high levels in the SCLC cases. For Bcl-2 (n=140), the hazard ratio for death if the staining was weak in intensity was 0.55 (0.33-0.94, P=0.03) and for ß(1)-integrin (n=151) was 0.60 (0.39-0.92, P=0.02). The meta-analysis showed an overall hazard ratio for low expression of Bcl-2 of 0.91(0.74-1.09).
CONCLUSIONS: Both Bcl-2 and ß(1)-integrin are independent prognostic factors in SCLC in this cohort although further validation is required to confirm their importance. A TMA of SCLC cases is feasible but challenging and an important tool for biomarker validation.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ITGB1Humanlung small cell carcinoma disease_progressionIEP  RGD 
Itgb1Ratlung small cell carcinoma disease_progressionISOITGB1 (Homo sapiens) RGD 
Itgb1Mouselung small cell carcinoma disease_progressionISOITGB1 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Itgb1  (integrin subunit beta 1)

Genes (Mus musculus)
Itgb1  (integrin beta 1 (fibronectin receptor beta))

Genes (Homo sapiens)
ITGB1  (integrin subunit beta 1)


Additional Information