RGD Reference Report - MicroRNA-365 inhibits proliferation, migration and invasion of glioma by targeting PIK3R3. - Rat Genome Database

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MicroRNA-365 inhibits proliferation, migration and invasion of glioma by targeting PIK3R3.

Authors: Zhu, Yonggang  Zhao, Hongguang  Rao, Min  Xu, Songbai 
Citation: Zhu Y, etal., Oncol Rep. 2017 Apr;37(4):2185-2192. doi: 10.3892/or.2017.5458. Epub 2017 Feb 16.
RGD ID: 13782053
Pubmed: PMID:28260020   (View Abstract at PubMed)
DOI: DOI:10.3892/or.2017.5458   (Journal Full-text)

A growing body of evidence suggests that microRNA-365 (miR-365) played crucial role in the initiation and development of many types of cancers. However, the biological role of miR-365 in human glioma remains unclear. Herein, the aims of this study were to investigate the role and underlying mechanisms of miR-365 in glioma by a series of in vitro and in vivo experiments. We found that miR-365 was strongly downregulated in malignant glioma tissues and cell lines. Restoration of the expression of miR-365 in glioma cells significantly inhibited cell proliferation, migration and invasion in vitro and tumor growth in vivo. Notably, phosphoinositide-3-kinase regulatory subunit 3 (PIK3R3) was proved to be a direct target of miR-365 in glioma cells, and its mRNA expression was inversely correlated with miR-365 expression in clinical glioma tissues. PIK3R3 overexpression in miR-365 expressing cells could rescue proliferation, migration and invasion inhibition of miR-365. In addition, miR-365 was able to inhibit the phosphorylation of AKT and mTOR in vitro and in vivo, which are key participants in the AKT/mTOR pathway. These results suggest that miR-365 functioned as a tumor suppressor in glioma by targeting PIK3R3, suggesting that miR-365 has potential as therapeutic targets for glioma.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
high grade glioma treatmentIEP 13782053 RGD 
high grade glioma treatmentISOPIK3R3 (Homo sapiens)13782053; 13782053 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pik3r3  (phosphoinositide-3-kinase regulatory subunit 3)

Genes (Mus musculus)
Pik3r3  (phosphoinositide-3-kinase regulatory subunit 3)

Genes (Homo sapiens)
PIK3R3  (phosphoinositide-3-kinase regulatory subunit 3)


Additional Information