RGD Reference Report - Nmnat2 protects cardiomyocytes from hypertrophy via activation of SIRT6. - Rat Genome Database

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Nmnat2 protects cardiomyocytes from hypertrophy via activation of SIRT6.

Authors: Cai, Yi  Yu, Shan-Shan  Chen, Shao-Rui  Pi, Rong-Biao  Gao, Si  Li, Hong  Ye, Jian-Tao  Liu, Pei-Qing 
Citation: Cai Y, etal., FEBS Lett. 2012 Mar 23;586(6):866-74. doi: 10.1016/j.febslet.2012.02.014. Epub 2012 Feb 20.
RGD ID: 13782043
Pubmed: (View Article at PubMed) PMID:22449973
DOI: Full-text: DOI:10.1016/j.febslet.2012.02.014

The discovery of sirtuins (SIRT), a family of nicotinamide adenine dinucleotide (NAD)-dependent deacetylases, has indicated that intracellular NAD level is crucial for the hypertrophic response of cardiomyocytes. Nicotinamide mononucleotide adenylyltransferase (Nmnat) is a central enzyme in NAD biosynthesis. Here we revealed that Nmnat2 protein expression and enzyme activity were down-regulated during cardiac hypertrophy. In neonatal rat cardiomyocytes, overexpression of Nmnat2 but not its catalytically inactive mutant blocked angiotensin II (Ang II)-induced cardiac hypertrophy, which was dependent on activation of SIRT6 through maintaining the intracellular NAD level. Our results suggested that modulation of Nmnat2 activity may be beneficial in cardiac hypertrophy.


Disease Annotations    

Gene Ontology Annotations    

Biological Process

Cellular Component
cytoplasm  (IDA)

Objects Annotated

Genes (Rattus norvegicus)
Nmnat2  (nicotinamide nucleotide adenylyltransferase 2)

Genes (Mus musculus)
Nmnat2  (nicotinamide nucleotide adenylyltransferase 2)

Genes (Homo sapiens)
NMNAT2  (nicotinamide nucleotide adenylyltransferase 2)

Additional Information